Innovative COVID-19 diagnostics and testing strategies in Italy, Denmark, UK, Israel and Sweden: a comparative analysis including tests, incidence and mortality: Innovative COVID-19 diagnostics and testing strategies

Background and aim: Detecting SARS-CoV-2 remains a critical component in the global effort to control COVID-19, particularly with the emergence of variants. Since the outbreak, diagnostic techniques have evolved to meet different contexts and needs. Methods: In this study, we analyzed the use of these tech- niques in five countries (i.e. Italy, Denmark, the United Kingdom, Sweden, and Israel) based on their specific national testing and contact tracing strategies. We also examined the number of tests performed per week, the positivity rate of tests, and the mortality rate in these populations during the same time periods. These countries were chosen based on the directives of the consortium involved in the CORONADX project. Results: During the three-year period under review, Italy and Denmark adopted large-scale testing strategies over a long period of time, with different results: in Italy an average of 4.5% of the population adhered to diagnosis, in Denmark 21%, while Israel reached 6.5%. The UK prioritised mass testing for short periods, outperforming the other countries with 1,882,596,198 total swabs and an average adherence of 28.1% of the population. Despite this, it recorded the highest number of deaths related to COVID-19 (211,155), with a lethality rate of 0.87%, second only to Sweden with 0.88%, where the average adherence to diagnosis was 1.7% of the population. Significant are the data for Israel, where as deaths increased, so did testing (r = 0.62, p < 0.001). Conclusions: To control future outbreaks it’s fundamental satisfying the need for effective testing strategies and government communication, equitable healthcare access, and education in public health and hygiene principles. (www.actabiomedica.it)