Bosentan blocks the antiangiogenic effects of sera from systemic sclerosis patients: an in vitro study
Academic Article
Publication Date:
2015
Short description:
Bosentan blocks the antiangiogenic effects of sera from systemic sclerosis patients: an in vitro study / Romano, E., BELLANDO RANDONE, S., Manetti, M., Bruni, C., Lepri, G., MATUCCI CERINIC, M., Guiducci, S.. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 33 Suppl 91:(2015), pp. 148-152.
abstract:
In systemic sclerosis (SSc), clinical evidence has shown that Bosentan may foster the regeneration of the peripheral microcirculatory network. The aim of this study was to verify in vitro the influence of Bosentan on the angiogenic performance of dermal microvascular endothelial cells (MVECs) and its possible capacity to counteract the antiangiogenic effects of SSc sera.
Iris type:
1.1 Articolo in rivista
Keywords:
Systemic sclerosis; endothelial cells; angiogenesis; endothelin-1; chemoinvasion; cell proliferation
List of contributors:
Romano, Eloisa; BELLANDO RANDONE, Silvia; Manetti, Mirko; Bruni, Cosimo; Lepri, Gemma; MATUCCI CERINIC, Marco; Guiducci, Serena
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