Mycophenolate mofetil for the treatment of juvenile onset SLE: a multicenter study

Mycophenolate mofetil (MMF) has proved to be an efficacious and safe therapy in adult lupus
nephritis. Recently, this drug has been suggested as a possible new alternative treatment also for
juvenile-onset SLE (juvenile-SLE). A multicenter study has been performed to evaluate the efficacy
and safety of MMF in controlling the disease activity in children and adolescents with juvenile-
SLE. Our results show that MMF was effective in reducing the disease activity or as a steroidsparing
agent in 14 of 26 patients (54%), stabilised the disease in 8 (31%) and was ineffective in 4
(15%). In particular, in patients without renal involvement, a good response was registered in 9 of
13 patients (69%). Among those patients with renal involvement, MMF was effective in 5 of 13
patients (38%), partially effective in 4 (31%) and ineffective in 4 (31%). No severe side effects have
been observed; only two patients stopped the drug because of severe diarrhoea and abdominal pain.
With the limits of a retrospective study, MMF seems to be effective and safe for the treatment of
juvenile-SLE, especially in patients with no renal involvement.