Prospective Cohort Study to Compare Long-Term Lung Cancer-Specific and All-Cause Survival of Clinical Early Stage (T1a–b; ≤20 mm) NSCLC Treated by Stereotactic Body Radiation Therapy and Surgery
Articolo
Data di Pubblicazione:
2024
Citazione:
Prospective Cohort Study to Compare Long-Term Lung Cancer-Specific and All-Cause Survival of Clinical Early Stage (T1a–b; ≤20 mm) NSCLC Treated by Stereotactic Body Radiation Therapy and Surgery / Henschke, C. I.; Yip, R.; Sun, Q.; Li, P.; Yankelevitz, D. F.; Henschke, C. I.; Sun, Q.; Li, P.; Kaufman, A.; Flores, R. M.; Samstein, R.; Rosenzweig, K.; Connery, C.; Kohman, L.; Lee, P.; Tannous, H.; Taioli, E.; Flores, R.; Kaufman, A.; Lee, D. -S.; Nicastri, D.; Wolf, A.; Song, K.; Rosenzweig, K.; Gomez, J.; Samstein, R.; Dutta, P.; Beasley, M. B.; Zakowski, M.; Chung, M.; Yankelevitz, D. F.; Henschke, C. I.; Taioli, E.; Schwartz, R.; Chan, H.; Zhu, J.; Kantor, S.; Woode, S.; Nicastri, D.; Hakami, A.; Buyuk, A.; Friedman, A.; Dreifuss, R.; Verzosa, S.; Yakubox, M.; Aloferdova, K.; Stacey, P.; De Nobrega, S.; Zhu, J.; Kantor, S.; Woode, S.; Hakami, A.; Zhu, J.; Kantor, S.; Woode, S.; Lentini, L.; Pass, H.; Cooper, B.; Moreirea, A.; Sorensen, A.; Kohman, L.; Dunton, R.; Wallen, J.; Curtiss, C.; Scalzetti, E.; Ellinwood, L.; Tannous, H.; Connery, C. P.; Torres, E.; Cruzer, D.; Gendron, B.; Alyea, S.; Krumholtz, P.; Watkins, A.; Servais, E.; Stock, C.; Mckee, A.; Lopez, E.; Hsu, H.; Hunter, K.; Lemons, J.; Nixon, A.; Osa, E. -O.; Lee, P.; Hyman, K.; Jurado, J.; Zeltman, D.; Glassman, L.; Sharma, R.; Singh, V.; Milhelis, E.; Karan, N.; Rzyman, W.; Dziedzic, R.; Flores, R.; Henschke, C.; Taioli, E.; Yankelevitz, D.; Schwartz, R.; Jirapatnakul, A.; Yip, R.; Chan, H.; Henschke, C. I.; Yankelevitz, D. F.; Yip, R.; Jirapatnakul, A.; Flores, R.; Kaufman, A.; Wolf, A.; Nicastri, D.; Zulueta, J. J.; Taioli, E.; Reeves, A. P.; Altorki, N. K.; Smith, J. P.; Libby, D. M.; Pasmantier, M.; Markowitz, S.; Miller, A.; Deval, J. C.; Shaham, D.; Seijo, L.; Bastarika, G.; Montuenga, L. M.; Spring, S.; Aylesworth, C.; Klingler, K.; Schob, O.; Andaz, S.; Straznicka, M.; Chin, C.; Weiser, T.; Sone, S.; Hanaoka, T.; Roberts, H.; Patsios, D.; Scopetuolo, M.; Brown, A.; Wu, N.; Cole, E.; Yeh, D.; Luedke, D.; Liu, X.; Herzog, G.; Aye, R.; Rifkin, M.; Veronesi, G.; Infante, M.; Vafai, D.; Kopel, S.; Taylor, J.; Thurer, R.; Villamizar, N.; Austin, J. H. M.; Pearson, G. D. N.; Klippenstein, D.; Litwin, A.; Loud, P. A.; Kohman, L. J.; Scalzetti, E. M.; Khan, A.; Shah, R.; Mayfield, W.; Frumiento, C.; Smith, M. V.; Thorsen, M. K.; Hansen, R.; Naidich, D.; Mcguinness, G.; Widmann, M.; Korst, R.; Lowry, J.; Salvatore, M.; Walsh, J.; Bertsch, D.; Scheinberg, P.; Sheppard, B.; Cecchi, G.; Ginsberg, M. S.; Welch, L.; Raz, D. J.; Rotter, A.; Connery, C.; Matalon, T. A. S.; Cheung, E. H.; Glassberg, R.; Olsen, D.; Mullen, D.; Odzer, S. -L.; Wiernik, P. H.; Ray, D.; Decunzo, L.; Pass, H.; Endress, C.; Vacca, A.; Kondapaneni, M.; Lim, M.; Kalafer, M.; Green, J.; Yoder, M.; Shah, P.; Camacho, E.; O'Brien, J.; Willey, J. C.; Gordon, D.; Kocha, A.. - In: JOURNAL OF THORACIC ONCOLOGY. - ISSN 1556-0864. - 19:3(2024), pp. 476-490. [10.1016/j.jtho.2023.10.002]
Abstract:
Introduction: We aimed to compare outcomes of patients with first primary clinical T1a-bN0M0 NSCLC treated with surgery or stereotactic body radiation therapy (SBRT). Methods: We identified patients with first primary clinical T1a-bN0M0 NSCLCs on last pretreatment computed tomography treated by surgery or SBRT in the following two prospective cohorts: International Early Lung Cancer Action Program (I-ELCAP) and Initiative for Early Lung Cancer Research on Treatment (IELCART). Lung cancer-specific survival and all-cause survival after diagnosis were compared using Kaplan-Meier analysis. Propensity score matching was used to balance baseline demographics and comorbidities and analyzed using Cox proportional hazards regression. Results: Of 1115 patients with NSCLC, 1003 had surgery and 112 had SBRT; 525 in I-ELCAP in 1992 to 2021 and 590 in IELCART in 2016 to 2021. Median follow-up was 57.6 months. Ten-year lung cancer-specific survival was not significantly different: 90% (95% confidence interval: 87%–92%) for surgery versus 88% (95% confidence interval: 77%–99%) for SBRT, p = 0.55. Cox regression revealed no significant difference in lung cancer-specific survival for the combined cohorts (p = 0.48) or separately for I-ELCAP (p = 1.00) and IELCART (p = 1.00). Although 10-year all-cause survival was significantly different (75% versus 45%, p < 0.0001), after propensity score matching, all-cause survival using Cox regression was no longer different for the combined cohorts (p = 0.74) or separately for I-ELCAP (p = 1.00) and IELCART (p = 0.62). Conclusions: This first prospectively collected cohort analysis of long-term survival of small, early NSCLCs revealed that lung cancer-specific survival was high for both treatments and not significantly different (p = 0.48) and that all-cause survival after propensity matching was not significantly different (p = 0.74). This supports SBRT as an alternative treatment option for small, early NSCLCs which is especially important with their increasing frequency owing to low-dose computed tomography screening. Furthermore, treatment decisions are influenced by many different factors and should be personalized on the basis of the unique circumstances of each patient.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Henschke, C. I.; Yip, R.; Sun, Q.; Li, P.; Yankelevitz, D. F.; Henschke, C. I.; Sun, Q.; Li, P.; Kaufman, A.; Flores, R. M.; Samstein, R.; Rosenzweig, K.; Connery, C.; Kohman, L.; Lee, P.; Tannous, H.; Taioli, E.; Flores, R.; Kaufman, A.; Lee, D. -S.; Nicastri, D.; Wolf, A.; Song, K.; Rosenzweig, K.; Gomez, J.; Samstein, R.; Dutta, P.; Beasley, M. B.; Zakowski, M.; Chung, M.; Yankelevitz, D. F.; Henschke, C. I.; Taioli, E.; Schwartz, R.; Chan, H.; Zhu, J.; Kantor, S.; Woode, S.; Nicastri, D.; Hakami, A.; Buyuk, A.; Friedman, A.; Dreifuss, R.; Verzosa, S.; Yakubox, M.; Aloferdova, K.; Stacey, P.; De Nobrega, S.; Zhu, J.; Kantor, S.; Woode, S.; Hakami, A.; Zhu, J.; Kantor, S.; Woode, S.; Lentini, L.; Pass, H.; Cooper, B.; Moreirea, A.; Sorensen, A.; Kohman, L.; Dunton, R.; Wallen, J.; Curtiss, C.; Scalzetti, E.; Ellinwood, L.; Tannous, H.; Connery, C. P.; Torres, E.; Cruzer, D.; Gendron, B.; Alyea, S.; Krumholtz, P.; Watkins, A.; Servais, E.; Stock, C.; Mckee, A.; Lopez, E.; Hsu, H.; Hunter, K.; Lemons, J.; Nixon, A.; Osa, E. -O.; Lee, P.; Hyman, K.; Jurado, J.; Zeltman, D.; Glassman, L.; Sharma, R.; Singh, V.; Milhelis, E.; Karan, N.; Rzyman, W.; Dziedzic, R.; Flores, R.; Henschke, C.; Taioli, E.; Yankelevitz, D.; Schwartz, R.; Jirapatnakul, A.; Yip, R.; Chan, H.; Henschke, C. I.; Yankelevitz, D. F.; Yip, R.; Jirapatnakul, A.; Flores, R.; Kaufman, A.; Wolf, A.; Nicastri, D.; Zulueta, J. J.; Taioli, E.; Reeves, A. P.; Altorki, N. K.; Smith, J. P.; Libby, D. M.; Pasmantier, M.; Markowitz, S.; Miller, A.; Deval, J. C.; Shaham, D.; Seijo, L.; Bastarika, G.; Montuenga, L. M.; Spring, S.; Aylesworth, C.; Klingler, K.; Schob, O.; Andaz, S.; Straznicka, M.; Chin, C.; Weiser, T.; Sone, S.; Hanaoka, T.; Roberts, H.; Patsios, D.; Scopetuolo, M.; Brown, A.; Wu, N.; Cole, E.; Yeh, D.; Luedke, D.; Liu, X.; Herzog, G.; Aye, R.; Rifkin, M.; Veronesi, G.; Infante, M.; Vafai, D.; Kopel, S.; Taylor, J.; Thurer, R.; Villamizar, N.; Austin, J. H. M.; Pearson, G. D. N.; Klippenstein, D.; Litwin, A.; Loud, P. A.; Kohman, L. J.; Scalzetti, E. M.; Khan, A.; Shah, R.; Mayfield, W.; Frumiento, C.; Smith, M. V.; Thorsen, M. K.; Hansen, R.; Naidich, D.; Mcguinness, G.; Widmann, M.; Korst, R.; Lowry, J.; Salvatore, M.; Walsh, J.; Bertsch, D.; Scheinberg, P.; Sheppard, B.; Cecchi, G.; Ginsberg, M. S.; Welch, L.; Raz, D. J.; Rotter, A.; Connery, C.; Matalon, T. A. S.; Cheung, E. H.; Glassberg, R.; Olsen, D.; Mullen, D.; Odzer, S. -L.; Wiernik, P. H.; Ray, D.; Decunzo, L.; Pass, H.; Endress, C.; Vacca, A.; Kondapaneni, M.; Lim, M.; Kalafer, M.; Green, J.; Yoder, M.; Shah, P.; Camacho, E.; O'Brien, J.; Willey, J. C.; Gordon, D.; Kocha, A.
Link alla scheda completa:
Pubblicato in: