Further Evidence for Amyloid Deposition in Clinical Pancreatic Islet Grafts

Background. The reasons for the long-term complete or partial loss of islet graft function are unknown, but there areobviously other reasons than just pure allogeneic graft rejection. Earlier studies have shown that deposition of isletamyloid polypeptide amyloid in transplanted islets may indicate a mechanism for loss of cells.Materials and Methods. Sections from liver material from four deceased islet-bearing recipients have been scrutinizedfor the presence of amyloid. Clinical data and certain aspects of the islet graft pathology of these patients have beenpublished previously.Result. With this extended histological analysis, we demonstrate the occurrence of amyloid deposits in islets transplantedinto the liver in three of four patients with type 1 diabetes.Conclusion. The finding adds evidence to the assumption that aggregation of islet amyloid polypeptide might be animportant cause of progressing -cell dysfunction in clinically transplanted islets.