Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Articolo
Data di Pubblicazione:
2010
Citazione:
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci / Franke, A.; Mcgovern, D. P. B.; Barrett, J. C.; Wang, K.; Radford-Smith, G. L.; Ahmad, T.; Lees, C. W.; Balschun, T.; Lee, J.; Roberts, R.; Anderson, C. A.; Bis, J. C.; Bumpstead, S.; Ellinghaus, D.; Festen, E. M.; Georges, M.; Green, T.; Haritunians, T.; Jostins, L.; Latiano, A.; Mathew, C. G.; Montgomery, G. W.; Prescott, N. J.; Raychaudhuri, S.; Rotter, J. I.; Schumm, P.; Sharma, Y.; Simms, L. A.; Taylor, K. D.; Whiteman, D.; Wijmenga, C.; Baldassano, R. N.; Barclay, M.; Bayless, T. M.; Brand, S.; Buning, C.; Cohen, A.; Colombel, J. -F.; Cottone, M.; Stronati, L.; Denson, T.; De Vos, M.; D'Inca, R.; Dubinsky, M.; Edwards, C.; Florin, T.; Franchimont, D.; Gearry, R.; Glas, J.; Van Gossum, A.; Guthery, S. L.; Halfvarson, J.; Verspaget, H. W.; Hugot, J. -P.; Karban, A.; Laukens, D.; Lawrance, I.; Lemann, M.; Levine, A.; Libioulle, C.; Louis, E.; Mowat, C.; Newman, W.; Panes, J.; Phillips, A.; Proctor, D. D.; Regueiro, M.; Russell, R.; Rutgeerts, P.; Sanderson, J.; Sans, M.; Seibold, F.; Steinhart, A. H.; Stokkers, P. C. F.; Torkvist, L.; Kullak-Ublick, G.; Wilson, D.; Walters, T.; Targan, S. R.; Brant, S. R.; Rioux, J. D.; D'Amato, M.; Weersma, R. K.; Kugathasan, S.; Griffiths, A. M.; Mansfield, J. C.; Vermeire, S.; Duerr, R. H.; Silverberg, M. S.; Satsangi, J.; Schreiber, S.; Cho, J. H.; Annese, V.; Hakonarson, H.; Daly, M. J.; Parkes, M.. - In: NATURE GENETICS. - ISSN 1061-4036. - 42:12(2010), pp. 1118-1125. [10.1038/ng.717]
Abstract:
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10 -8). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease. © 2010 Nature America, Inc. All rights reserved.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Franke, A.; Mcgovern, D. P. B.; Barrett, J. C.; Wang, K.; Radford-Smith, G. L.; Ahmad, T.; Lees, C. W.; Balschun, T.; Lee, J.; Roberts, R.; Anderson, C. A.; Bis, J. C.; Bumpstead, S.; Ellinghaus, D.; Festen, E. M.; Georges, M.; Green, T.; Haritunians, T.; Jostins, L.; Latiano, A.; Mathew, C. G.; Montgomery, G. W.; Prescott, N. J.; Raychaudhuri, S.; Rotter, J. I.; Schumm, P.; Sharma, Y.; Simms, L. A.; Taylor, K. D.; Whiteman, D.; Wijmenga, C.; Baldassano, R. N.; Barclay, M.; Bayless, T. M.; Brand, S.; Buning, C.; Cohen, A.; Colombel, J. -F.; Cottone, M.; Stronati, L.; Denson, T.; De Vos, M.; D'Inca, R.; Dubinsky, M.; Edwards, C.; Florin, T.; Franchimont, D.; Gearry, R.; Glas, J.; Van Gossum, A.; Guthery, S. L.; Halfvarson, J.; Verspaget, H. W.; Hugot, J. -P.; Karban, A.; Laukens, D.; Lawrance, I.; Lemann, M.; Levine, A.; Libioulle, C.; Louis, E.; Mowat, C.; Newman, W.; Panes, J.; Phillips, A.; Proctor, D. D.; Regueiro, M.; Russell, R.; Rutgeerts, P.; Sanderson, J.; Sans, M.; Seibold, F.; Steinhart, A. H.; Stokkers, P. C. F.; Torkvist, L.; Kullak-Ublick, G.; Wilson, D.; Walters, T.; Targan, S. R.; Brant, S. R.; Rioux, J. D.; D'Amato, M.; Weersma, R. K.; Kugathasan, S.; Griffiths, A. M.; Mansfield, J. C.; Vermeire, S.; Duerr, R. H.; Silverberg, M. S.; Satsangi, J.; Schreiber, S.; Cho, J. H.; Annese, V.; Hakonarson, H.; Daly, M. J.; Parkes, M.
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