Understanding local immunity to enable regionalized medicine

The adaptation of immune cells to their local microenvironments in our body is central to tissue homeostasis and linked to disease. In this commentary, we envision how future therapeutics could leverage local immunity to selectively target specific niches for disease treatment.This commentary of the Sparks of Science series from the Catalysts program discusses how dissection of local immunity paves the way for the selective targeting of specific niches in future therapeutics.