Response to SSRIs and role of the hormonal therapy in post-menopausal depression

The aim of this study is to prospectively evaluate the antidepressant response to SSRIs in depressed post-menopausat women with or without hormonal therapy (FIT), and to analyze the possible influence of basal serum Levels of gonadotropins and sexual hormones on the antidepressant response. 170 post-menopausal women with a depressive episode (DSM-IV criteria) - 47 on HT and 123 not on HT - started the treatment with an SSRI. Depressive symptoms were assessed at baseline and 7 weeks thereafter by raters blind to treatment regimen. Response rates were 63.2% in the group without HT and 83.7% in the HT group (p = 0. 013). An inverse correlation emerged between the basal levels of LH and the improvement in HRSD scores (p = 0.001) in the group without HT In conclusion, HT appeared to improve the antidepressant response to SSRIs. Furthermore, in post-menopausal women, LH basal levels may be taken into account as possible predictor of response. (C) 2006 Elsevier B.V. and ECNR All rights reserved.