Deciphering the Complexity: Nephrotic Syndrome in Autosomal Dominant Polycystic Kidney Disease – A Case Report and Literature Review

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder marked by the formation of multiple kidney cysts and an increase in overall kidney volume, which frequently results in progressive kidney failure. Although glomerulonephritis can potentially occur as a complication, it is considered uncommon among patients with ADPKD, and the occurrence of nephrotic syndrome in this group is very rare. We report a case involving a young woman with ADPKD who developed nephrotic syndrome, likely attributed to minimal change disease. This review thoroughly examines the diagnostic challenges, management approaches, and current literature regarding this rare connection.