Ring chromosome 10 (p15q26) in a patient with unipolar affective disorder, multiple minor anomalies, and mental retardation

For several psychiatric diseases such as schizophrenia and autism, an involvement of genes in genesis of the illness has been suggested. Many studies have reported an association between chromosomal abnormalities and psychiatric disorders. Recently linkage studies have been conducted in families with mood disorders and although no gene has yet been identified, regions of interest of several chromosomes have been identified. We report on a patient with ring chromosome 10 (p15q26) presenting with mild dysmorphic features, moderate mental retardation, and an unipolar affective disorder. Extensive fluorescence in situ hybridization (FISH) experiments were performed to locate the breakpoints on ring chromosome 10. This study suggests the possibility of a correlation between a mood disorder and deletion on chromosome 10 q26.