Autofluorescence in Adult-Onset Foveomacular Vitelliform Dystrophy

Purpose Yo describe fundus autofluorescence (FAF) characteristics of Adult-onset Foveomacular Vitelliform Dystrophy (AOFVD) and to find a correlation with the functional responses. Methods Patients affected by AOFVD underwent a complete ophthalmologic examination, including ETDRS visual acuity, blue-light autofluorescence (BL-FAF) and near-infrared autofluorescence (NIR-FAF) performed using the HRA confocal scanning laser ophthalmoscope, and microperimetry (MP-1 Microperimeter, Nidek). Results 15 patients affected by AOFVD were enrolled. Three different patterns were identified on BL-FAF and 2 on NIR-AF. Patchy pattern both on BL-FAF and on NIR-FAF reveal the worst functional response, showing lowest visual acuity and retinal sensitivity values. Conclusions A functional correlate with visual acuity and retinal sensitivity, measured by means of microperimetry, can be found. Longitudinal studies investigating the natural course of FAF patterns of AOFVD may be useful both to identify genetic influence and prognostic factors, and to determine specific clinical and functional correlates.