Data di Pubblicazione:
2019
Citazione:
Glucose metabolism during tumorigenesis in the genetic mouse model of pancreatic cancer / Pasquale, Valentina; Dugnani, Erica; Liberati, Daniela; Marra, Paolo; Citro, Antonio; Canu, Tamara; Policardi, Martina; Valla, Libera; Esposito, Antonio; Piemonti, Lorenzo. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - (2019). [Epub ahead of print] [10.1007/s00592-019-01335-4]
Abstract:
More than 40% of pancreatic ductal adenocarcinoma (PDAC) patients have glucose intolerance or diabetes. The association has led to two hypotheses: PDAC causes diabetes or diabetes shares risk factors for the development of PDAC. In order to elucidate the relationship between diabetes and PDAC, we investigated the glucose metabolism during tumorigenesis in the LSL-KrasG12D/+; LSL-Trp53R172H/+; and Pdx-1-Cre (KPC) mouse, a genetically engineered model of PDAC.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Diabetes; High-fat diet; KPC; Pancreatic cancer; Staging
Elenco autori:
Pasquale, Valentina; Dugnani, Erica; Liberati, Daniela; Marra, Paolo; Citro, Antonio; Canu, Tamara; Policardi, Martina; Valla, Libera; Esposito, Antonio; Piemonti, Lorenzo
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