A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8
Articolo
Data di Pubblicazione:
2019
Citazione:
A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8 / Nardelli, F., Ghitti, M., Quilici, G., Gori, A., Luo, Q., Berardi, A., Sacchi, A., Monieri, M., Bergamaschi, G., Bermel, W., Chen, F., Corti, A., Curnis, F., Musco, G.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 55:98(2019), pp. 14777-14780. [10.1039/c9cc08518a]
Abstract:
Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Amino Acid Sequence; Antigens, Neoplasm; Cell Line, Tumor; Chromogranin A; Humans; Integrins; Ligands; Microscopy, Fluorescence; Nuclear Magnetic Resonance, Biomolecular; Peptides; Protein Binding
Elenco autori:
Nardelli, F.; Ghitti, M.; Quilici, G.; Gori, A.; Luo, Q.; Berardi, A.; Sacchi, A.; Monieri, M.; Bergamaschi, G.; Bermel, W.; Chen, F.; Corti, A.; Curnis, F.; Musco, G.
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