Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor
Articolo
Data di Pubblicazione:
2020
Citazione:
Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor / Gadaleta, R.M., Garcia-Irigoyen, O., Cariello, M., Scialpi, N., Peres, C., Vetrano, S., Fiorino, G., Danese, S., Ko, B., Luo, J., Porru, E., Roda, A., Sabbà, C., Moschetta, A.. - In: EBIOMEDICINE. - ISSN 2352-3964. - 54:(2020), p. 102719. [10.1016/j.ebiom.2020.102719]
Abstract:
Disruption of bile acid (BA) homeostasis plays a key role in intestinal inflammation. The gut-liver axis is the main site for the regulation of BA synthesis and BA pool size via the combined action of the nuclear Farnesoid X Receptor (FXR) and the enterokine Fibroblast Growth Factor 19 (FGF19). Increasing evidence have linked derangement of BA metabolism with dysbiosis and mucosal inflammation. Thus, here we aimed to investigate the potential action of an FGF19 analogue on intestinal microbiota and inflammation.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Bile acids; DSS-colitis; Enterokine; Intestinal inflammation; Nuclear receptors; Animals; Anti-Inflammatory Agents; Bile Acids and Salts; Colitis; Ulcerative; Crohn Disease; Female; Fibroblast Growth Factors; Humans; Male; Mice; Mice; Inbred C57BL; Peptides; Receptors; Cytoplasmic and Nuclear; Recombinant Proteins; Gastrointestinal Microbiome
Elenco autori:
Gadaleta, Raffaella Maria; Garcia-Irigoyen, Oihane; Cariello, Marica; Scialpi, Natasha; Peres, Claudia; Vetrano, Stefania; Fiorino, Gionatha; Danese, Silvio; Ko, Brian; Luo, Jian; Porru, Emanuele; Roda, Aldo; Sabbà, Carlo; Moschetta, Antonio
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