Transcriptional effects of fingolimod treatment on peripheral T cells in relapsing remitting multiple sclerosis patients
Academic Article
Publication Date:
2022
Short description:
Transcriptional effects of fingolimod treatment on peripheral T cells in relapsing remitting multiple sclerosis patients / Sferruzza, G., Clarelli, F., Mascia, E., Ferrè, L., Ottoboni, L., Sorosina, M., Santoro, S., Filippi, M., Provero, P., Esposito, F.. - In: PHARMACOGENOMICS. - ISSN 1462-2416. - 23:3(2022), pp. 161-171. [10.2217/pgs-2021-0118]
abstract:
Aim: To investigate the transcriptional changes induced by Fingolimod (FTY) in T cells of relapsing remitting multiple sclerosis patients. Patients & methods: Transcriptomic changes after 6 months of FTY therapy were evaluated on T cells from 24 relapsing remitting multiple sclerosis patients through RNA-sequencing, followed by technical validation and pathway analysis. Results: Among differentially expressed genes, CX3CR1 and CCR7 resulted strongly up- and down-regulated, respectively. Two relevant genes were validated with quantitative PCR and we largely confirmed findings from two previous microarray-based studies with similar design. Pathway analysis pointed to an involvement of processes related to immune function and cell migration. Conclusion: Our data support the evidence that FTY induces major transcriptional changes in genes involved in immune response and cell trafficking in T lymphocytes.
Iris type:
1.1 Articolo in rivista
Keywords:
Fingolimod; T lymphocytes; multiple sclerosis; pathway analysis; transcriptomic profile
List of contributors:
Sferruzza, Giacomo; Clarelli, Ferdinando; Mascia, Elisabetta; Ferrè, Laura; Ottoboni, Linda; Sorosina, Melissa; Santoro, Silvia; Filippi, Massimo; Provero, Paolo; Esposito, Federica
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