Hemochromatosis

Hemochromatosis is an iron-overload syndrome that includes a hereditary and an acquired form The main cutaneous manifestations are a brownish bronze to slate gray hyperpigmentation due to hemosiderin deposition, hair loss most commonly involving the pubic region, koilonychias, icthyosiform alterations, and generalized pruritus Hyperpigmentation is a very important diagnostic sign, as early treatment with phlebotomy and chelating agents improve the prognosis significantly and even reverses the systemic and skin manifestations © 2010 Springer Science+Business Media, LLC.