Colloid milium

Colloid milium is a rare, degenerative skin condition characterized by deposition of amorphous hyaline-like material in the dermis. Colloid milium and colloid degeneration include at least four distinct clinicopathological conditions: classic adult-type colloid milium, juvenile colloid milium, nodular-colloid degeneration (paracolloid), and pigmented colloid milium (hydroquinone related). There are usually no systemic implications, with the exception of a rare ligneous conjunctivitis or periodontitis in the juvenile type. Special stains, immunohistochemical studies, and electron microscopy have allowed the distinction from similar conditions such as amyloidosis. © 2010 Springer Science+Business Media, LLC.