Corticotroph aggressive pituitary tumours and carcinomas frequently harbour ATRX mutations

Academic Article
Publication Date:
2021
Short description:
Corticotroph aggressive pituitary tumours and carcinomas frequently harbour ATRX mutations / Casar-Borota, Olivera; Boldt, Henning Bünsow; Engström, Britt Edén; Andersen, Marianne Skovsager; Baussart, Bertrand; Bengtsson, Daniel; Berinder, Katarina; Ekman, Bertil; Feldt-Rasmussen, Ulla; Höybye, Charlotte; Jørgensen, Jens Otto L; Kolnes, Anders Jensen; Korbonits, Márta; Rasmussen, Åse Krogh; Lindsay, John R; Loughrey, Paul Benjamin; Maiter, Dominique; Manojlovic-Gacic, Emilija; Pahnke, Jens; Poliani, Pietro Luigi; Popovic, Vera; Ragnarsson, Oskar; Schalin-Jäntti, Camilla; Scheie, David; Tóth, Miklós; Villa, Chiara; Wirenfeldt, Martin; Kunicki, Jacek; Burman, Pia. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - 106:4(2021), pp. 1183-1194. [10.1210/clinem/dgaa749]
abstract:
Aggressive pituitary tumours (APTs) are characterised by unusually rapid growth and lack of response to standard treatment. About 1-2% develop metastases being classified as pituitary carcinomas (PCs). For unknown reasons, the corticotroph tumours are overrepresented amongst APTs and PCs. Mutations in the ATRX gene, regulating chromatin remodelling and telomere maintenance, have been implicated in the development of several cancer types, including neuroendocrine tumours.
Iris type:
1.1 Articolo in rivista
List of contributors:
Handle:
https://iris.unisr.it/handle/20.500.11768/162514
Full Text:
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THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Journal