Obesity and Protein kinase Cε epsilon expression in peripheral blood cells

The so-called Metabolic Syndrome is a clustering of metabolic disorders, including insulin resistance, obesity, hyperglycemia, dyslipidemia, and hypertension, mainly caused by overnutrition and sedentary lifestyles particularly in developed countries as well as genetic predisposition. Obesity, insulin resistance and type 2 diabetes are associated and caused by the upregulation of the protein kinase C (PKC)e expression in hepatic, adipose, pancreatic and skeletal tissue. It is well known that PKCe affects insulin receptor (IR) singaling and regulates both insulin secretion and clearance. Here, we have studied the expression levels of PKCe and IR in peripheral blood cells of obese children. Moreover, we have analyzed the correlation between PKCe/IR ratio with the BMI in adult underwent to high caloric food diet. As a final point, the role of PKCe as therapeutic target for management of obesity was discussed.