Design of microfluidic devices for drug screening on in-vitro cells for osteoporosis therapies
Academic Article
Publication Date:
2011
abstract:
The present work is aimed at the design and fabrication of microfluidic devices for pharmacological
in-vitro tests on cells as a tool for individuating the concentration range in which the drug effectiveness
is guaranteed, with particular attention to anti-osteoporotic therapies with strontium ranelate.
The microsystem consists of a microchannels network for the delivery and mixing of chemical species,
designed to provide a controlled drug concentration to each cell culture [1].
The design and the optimization of the microfluidic network were carried out by means of both analytical
and computational approaches. Besides, micromixers and wells modules were modeled, fabricated
and tested separately.
A prototype of the complete device has been produced and further experimental tests will be
performed.
in-vitro tests on cells as a tool for individuating the concentration range in which the drug effectiveness
is guaranteed, with particular attention to anti-osteoporotic therapies with strontium ranelate.
The microsystem consists of a microchannels network for the delivery and mixing of chemical species,
designed to provide a controlled drug concentration to each cell culture [1].
The design and the optimization of the microfluidic network were carried out by means of both analytical
and computational approaches. Besides, micromixers and wells modules were modeled, fabricated
and tested separately.
A prototype of the complete device has been produced and further experimental tests will be
performed.
Iris type:
1.1 Articolo in rivista
Keywords:
Microfluidic network; Cell culture; Osteoporosis; CFD; PDMS
List of contributors:
F., Nason; E., Morganti; C., Collini; C., Ress; S., Bersini; G., Pennati; F., Boschetti; A., Colombini; G., Lombardi; Banfi, Giuseppe; L., Lorenzelli; G., Dubini
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