Publication Date:
2024
Short description:
Epigenetic checkpoints regulate the fate and function of CAR-T cells / Casucci, M., Bonini, C., Ruggiero, E.. - In: NATURE IMMUNOLOGY. - ISSN 1529-2908. - 25:1(2024), pp. 4-6. [10.1038/s41590-023-01708-6]
abstract:
T cells exist in many functional states, and dynamic transitions from one state to another affect the outcome of adoptive T cell therapy. FOXP1 and KLF2 are now identified as transcriptional regulators of the stemness of CD8+ CAR-T cells and the bifurcation of stem-like CD8+ CAR-T cells into effector and exhausted subsets, respectively.
Iris type:
1.1 Articolo in rivista
List of contributors:
Casucci, Monica; Bonini, Chiara; Ruggiero, Eliana
Published in: