PDE5i therapy

Phosphodietserases-5 inhibitors (PDE5is) are currently the first line oral treatment for erectile dysfunction (ED) even though they can have potential role in slowing down plaque formation in Peyronie’s disease (PD). Several studies on animal models showed that PDE5is have anti-fibrotic properties that might help to relieve fibrotic plaques along with diffused corpora cavernosa fibrosis. Moreover, clinical studies using PDE5is alone or in combination with other medical treatments have shown promising results in reducing plaque fibrosis in patients with PD. Additionally, PDE5is play a fundamental role in patients developing ED after PD onset due to penile deformity, pain, narrowing, shortening and, curvature upon erections. Likewise, ED can occur after surgery for PD; in this context PDE5is are vital to restore proper erectile function.