Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain
Academic Article
Publication Date:
2018
Short description:
Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain / Monteleone, F., Nicoletti, C.G., Stampanoni Bassi, M., Iezzi, E., Buttari, F., Furlan, R., Finardi, A., Marfia, G.A., Centonze, D., Mori, F.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 314:(2018), pp. 89-93. [10.1016/j.jneuroim.2017.11.012]
abstract:
Central neuropathic pain (CNP) is common and disabling among patients with multiple sclerosis (MS). The pathological mechanisms underlying CNP in MS are not well understood. We explored whether NGF is implicated in the pathogenesis of CNP in MS. We measured NGF concentration in the CSF of 73 patients affected by MS, 15 with and 58 without CNP and 14 controls. We found increased levels of NGF in the CSF of patients with CNP compared to patients without and to controls. This finding supports the hypothesis that NGF plays a role in MS related CNP.
Iris type:
1.1 Articolo in rivista
Keywords:
Inflammation; MS; Nerve growth factor; Neurotrophins
List of contributors:
Monteleone, F.; Nicoletti, C. G.; Stampanoni Bassi, M.; Iezzi, E.; Buttari, F.; Furlan, R.; Finardi, A.; Marfia, G. A.; Centonze, D.; Mori, F.
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