Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy: The RESTYLE-HCM Randomized, Double-Blind, Placebo-Controlled Study
Academic Article
Publication Date:
2018
Short description:
Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy: The RESTYLE-HCM Randomized, Double-Blind, Placebo-Controlled Study / Olivotto, Iacopo; Camici, Paolo G; Merlini, Piera Angelica; Rapezzi, Claudio; Patten, Monica; Climent, Vicent; Sinagra, Gianfranco; Tomberli, Benedetta; Marin, Francisco; Ehlermann, Philipp; Maier, Lars S; Fornaro, Alessandra; Jacobshagen, Claudius; Ganau, Antonello; Moretti, Luciano; Hernandez Madrid, Antonio; Coppini, Raffaele; Reggiardo, Giorgio; Poggesi, Corrado; Fattirolli, Francesco; Belardinelli, Luiz; Gensini, Gianfranco; Mugelli, Alessandro. - In: CIRCULATION. HEART FAILURE. - ISSN 1941-3289. - 11:1(2018), p. e004124. [10.1161/CIRCHEARTFAILURE.117.004124]
abstract:
The late sodium current inhibitor ranolazine reverses the main electrophysiological and mechanical abnormalities of human hypertrophic cardiomyopathy (HCM) cardiomyocytes in vitro, suggesting potential clinical benefit. We aimed to assess the effect of ranolazine on functional capacity, symptomatic status, diastolic function, and arrhythmias in HCM.
Iris type:
1.1 Articolo in rivista
Keywords:
cardiomyopathy, hypertrophic; exercise test; quality of life; ranolazine; ventricular premature complexes
List of contributors:
Olivotto, Iacopo; Camici, Paolo G; Merlini, Piera Angelica; Rapezzi, Claudio; Patten, Monica; Climent, Vicent; Sinagra, Gianfranco; Tomberli, Benedetta; Marin, Francisco; Ehlermann, Philipp; Maier, Lars S; Fornaro, Alessandra; Jacobshagen, Claudius; Ganau, Antonello; Moretti, Luciano; Hernandez Madrid, Antonio; Coppini, Raffaele; Reggiardo, Giorgio; Poggesi, Corrado; Fattirolli, Francesco; Belardinelli, Luiz; Gensini, Gianfranco; Mugelli, Alessandro
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