A prospective study on the natural history of patients with profound combined immunodeficiency: An interim analysis
Academic Article
Publication Date:
2017
Short description:
A prospective study on the natural history of patients with profound combined immunodeficiency: An interim analysis / Speckmann, C., Doerken, S., Aiuti, A., Albert, M.H., Al-Herz, W., Allende, L.M., Scarselli, A., Avcin, T., Perez-Becker, R., Cancrini, C., Cant, A., Di Cesare, S., Finocchi, A., Fischer, A., Gaspar, H.B., Ghosh, S., Gennery, A., Gilmour, K., González-Granado, L.I., Martinez-Gallo, M., et al.. - In: THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. - ISSN 1097-6825. - 139:4(2017), p. 1302-1310.e4. [10.1016/j.jaci.2016.07.040]
abstract:
Absent T-cell immunity resulting in life-threatening infections provides a clear rationale for hematopoetic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency (SCID). Combined immunodeficiencies (CIDs) and "atypical" SCID show reduced, not absent T-cell immunity. If associated with infections or autoimmunity, they represent profound combined immunodeficiency (P-CID), for which outcome data are insufficient for unambiguous early transplant decisions.
Iris type:
1.1 Articolo in rivista
List of contributors:
Speckmann, Carsten; Doerken, Sam; Aiuti, Alessandro; Albert, Michael H; Al-Herz, Waleed; Allende, Luis M; Scarselli, Alessia; Avcin, Tadej; Perez-Becker, Ruy; Cancrini, Caterina; Cant, Andrew; Di Cesare, Silvia; Finocchi, Andrea; Fischer, Alain; Gaspar, H Bobby; Ghosh, Sujal; Gennery, Andrew; Gilmour, Kimberly; González-Granado, Luis I; Martinez-Gallo, Monica; Hambleton, Sophie; Hauck, Fabian; Hoenig, Manfred; Moshous, Despina; Neven, Benedicte; Niehues, Tim; Notarangelo, Luigi; Picard, Capucine; Rieber, Nikolaus; Schulz, Ansgar; Schwarz, Klaus; Seidel, Markus G; Soler-Palacin, Pere; Stepensky, Polina; Strahm, Brigitte; Vraetz, Thomas; Warnatz, Klaus; Winterhalter, Christine; Worth, Austen; Fuchs, Sebastian; Uhlmann, Annette; Ehl, Stephan
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