The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes
Academic Article
Publication Date:
2018
abstract:
Glutamate decarboxylase (GAD) antibodies are the most widely used predictive marker for Type 1 diabetes, but many individuals currently found to be GAD antibody-positive are unlikely to develop diabetes. We have shown previously that radioimmunoassays using N-terminally truncated35S-GAD65(96-585) offer better disease specificity with similar sensitivity to full-length35S-GAD65(1-585). To determine whether assay performance could be improved further, we evaluated a more radically truncated35S-GAD65(143-585) radiolabel.
Iris type:
1.1 Articolo in rivista
List of contributors:
Wyatt, R C; Brigatti, C; Liberati, D; Grace, S L; Gillard, B T; Long, A E; Marzinotto, I; Shoemark, D; Chandler, K A; Achenbach, P; Gillespie, K M; Piemonti, L; Lampasona, V; Williams, A J K
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