Impact of IL-32 on histamine release by human derived umbilical cord blood mast cells
Academic Article
Publication Date:
2009
abstract:
IL-32 is onae of the last important cytokines discovered, produced mainly by T cells, natural killer cells, and epithelial cells. Probably many other different cells are a source of IL-32, which has been found to be a powerful pro-inflammatory mediator. Here we studied the effect of IL-32 on histamine release by human-derived cord-blood mast cells. In these studies we found that IL-32 significantly stimulates the release of histamine only at high concentrations (100 ng/ml) while at 10 or 50 ng/ml it had no effect. These results were found for the first time and demonstrate that IL-32 may play an important role in allergic and inflammatory diseases. Copyright © by BIOLIFE, s.a.s.
Iris type:
1.1 Articolo in rivista
Keywords:
Cytokines; IL-32; Mast cells; Immunology and Allergy; Immunology
List of contributors:
Castellani, Maria Luisa; Toniato, E.; Felaco, P.; Ciampoli, C.; De Amicis, D.; Orso, C.; Cucurullo, C.; Vecchiet, J.; Tetè, S.; Salini, V.; Caraffa, A.; Pandolfi, F.; Antinolfi, P. L.; Cerulli, G.; Conti, F.; Fulcheri, M.; Sabatino, G.; Boscolo, P.; Shaik, Y. B.
Published in: