Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier
Academic Article
Publication Date:
2019
abstract:
The microvasculature of the central nervous system includes the blood-brain barrier (BBB), which regulates the permeability to nutrients and restricts the passage of toxic agents and inflammatory cells. Canonical Wnt/β-catenin signaling is responsible for the early phases of brain vascularization and BBB differentiation. However, this signal declines after birth, and other signaling pathways able to maintain barrier integrity at postnatal stage are still unknown.
Iris type:
1.1 Articolo in rivista
Keywords:
Wnt/β-catenin; blood-brain barrier; endothelial cells; permeability; stroke
List of contributors:
Corada, Monica; Orsenigo, Fabrizio; Bhat, Ganesh Parameshwar; Conze, Lei Liu; Breviario, Ferruccio; Cunha, Sara Isabel; Claesson-Welsh, Lena; Beznoussenko, Galina V; Mironov, Alexander A; Bacigaluppi, Marco; Martino, Gianvito; Pitulescu, Mara E; Adams, Ralf H; Magnusson, Peetra; Dejana, Elisabetta
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