Glucose metabolism during tumorigenesis in the genetic mouse model of pancreatic cancer
Academic Article
Publication Date:
2019
Short description:
Glucose metabolism during tumorigenesis in the genetic mouse model of pancreatic cancer / Pasquale, Valentina; Dugnani, Erica; Liberati, Daniela; Marra, Paolo; Citro, Antonio; Canu, Tamara; Policardi, Martina; Valla, Libera; Esposito, Antonio; Piemonti, Lorenzo. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - (2019). [Epub ahead of print] [10.1007/s00592-019-01335-4]
abstract:
More than 40% of pancreatic ductal adenocarcinoma (PDAC) patients have glucose intolerance or diabetes. The association has led to two hypotheses: PDAC causes diabetes or diabetes shares risk factors for the development of PDAC. In order to elucidate the relationship between diabetes and PDAC, we investigated the glucose metabolism during tumorigenesis in the LSL-KrasG12D/+; LSL-Trp53R172H/+; and Pdx-1-Cre (KPC) mouse, a genetically engineered model of PDAC.
Iris type:
1.1 Articolo in rivista
Keywords:
Diabetes; High-fat diet; KPC; Pancreatic cancer; Staging
List of contributors:
Pasquale, Valentina; Dugnani, Erica; Liberati, Daniela; Marra, Paolo; Citro, Antonio; Canu, Tamara; Policardi, Martina; Valla, Libera; Esposito, Antonio; Piemonti, Lorenzo
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