Highly satisfactory alkynylation of alkenyl halides via Pd-catalyzed cross-coupling with alkynylzincs and its critical comparison with the Sonogashira alkynylation
Academic Article
Publication Date:
2003
Short description:
Highly satisfactory alkynylation of alkenyl halides via Pd-catalyzed cross-coupling with alkynylzincs and its critical comparison with the Sonogashira alkynylation / Negishi, E.; Quian, M.; Zeng, F.; Anastasia, L.; Babinski, D.. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 5:10(2003), pp. 1597-1600. [10.1021/ol030010F]
abstract:
The Pd-catalyzed alkynylation of various alkenyl halides and triflates with alkynylzincs proceeds well even with alkynyl derivatives containing electron-withdrawing groups. The reaction appears to be highly general. Noteworthy is that the corresponding Sonogashira reactions under various reported conditions are significantly less satisfactory in all cases performed in this study.
Iris type:
1.1 Articolo in rivista
Keywords:
Carbon bond formation; conjugated diynes; diastereoselective synthesis; multidrug-resistance; general-synthesis; convenient route; aryl halides; palladium; efficient; organozincs
List of contributors:
Negishi, E.; Quian, M.; Zeng, F.; Anastasia, L.; Babinski, D.
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