Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer
Academic Article
Publication Date:
2011
Short description:
Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer / Kalimutho, M.; Di Cecilia, S.; Blanco G., Del Vecchio; Roviello, F.; Sileri, P; Cretella, M.; Formosa, A.; Corso, G.; Marrelli, D.; Pallone, F.; Federici, G.; Bernardini, S.. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - 104:11(2011), pp. 1770-1778. [10.1038/bjc.2011.82]
abstract:
MicroRNAs are tiny non-coding small endogenous RNAs that regulate gene expression by translational repression, mRNA cleavage and mRNA inhibition. The aim of this study was to investigate the hypermethylation of miR-34b/c and miR-148a in colorectal cancer, and correlate this data to clinicopathological features. We also aimed to evaluate the hypermethylation of miR-34b/c in faeces specimens as a novel non-invasive faecal-DNA-based screening marker.
Iris type:
1.1 Articolo in rivista
Keywords:
MicroRNAs; Gene Silencing; Humans; Disease Progression; Aged; Cell Line; Tumor; DNA Methylation; Aged; 80 and over; Adult; Azacitidine; Middle Aged; Feces; Tumor Markers; Biological; Colorectal Neoplasms; Female; Male
List of contributors:
Kalimutho, M.; Di Cecilia, S.; Blanco G., Del Vecchio; Roviello, F.; Sileri, P; Cretella, M.; Formosa, A.; Corso, G.; Marrelli, D.; Pallone, F.; Federici, G.; Bernardini, S.
Published in: