A simplified, non-invasive fecal-based DNA integrity assay and iFOBT for colorectal cancer detection
Academic Article
Publication Date:
2011
Short description:
A simplified, non-invasive fecal-based DNA integrity assay and iFOBT for colorectal cancer detection / Kalimutho, M; Del Vecchio Blanco, G; Cretella, M; Mannisi, E; Sileri, P; Formosa, A; Pallone, F; Federici, G; Bernardini, S. - In: INTERNATIONAL JOURNAL OF COLORECTAL DISEASE. - ISSN 0179-1958. - 26:5(2011), pp. 583-592. [10.1007/s00384-010-1128-x]
abstract:
Neoplasia cells exfoliated from colorectal epithelium have dysfunctional apoptotic mechanisms, thus it is possible to identify high-molecular weight DNA fragments in feces. This prospective single-center study was performed to evaluate the sensitivity and specificity of fecal-based DNA integrity versus immunological fecal occult blood test (iFOBT) and calprotectin for colorectal cancer (CRC) and adenoma detection.
Iris type:
1.1 Articolo in rivista
Keywords:
Sensitivity and Specificity; Regression Analysis; Nucleic Acid Denaturation; Occult Blood; ROC Curve; Humans; Biological Assay; Aged; Chromatography; High Pressure Liquid; Colonoscopy; Leukocyte L1 Antigen Complex; Aged; 80 and over; Adult; DNA; Middle Aged; Feces; Adenoma; Male; Colorectal Neoplasms; Female
List of contributors:
Kalimutho, M; Del Vecchio Blanco, G; Cretella, M; Mannisi, E; Sileri, P; Formosa, A; Pallone, F; Federici, G; Bernardini, S
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