IANNACONE MATTEO

Matteo Iannacone, MD, PhD

Director, Division of Immunology
Professor of Pathology
Head, Dynamics of Immune Responses
San Raffaele Scientific Institute & University
Via Olgettina, 58 – 20132 Milano, ITALY
+39 (348) 853-3711 • iannacone.matteo@hsr.it •
www.iannaconelab.com • Twitter: @iannaconelab
Married, two children (born 2013 and 2016)

ORCID ID: 0000-0002-9370-2671
Scopus Author ID: 6507012016
Researcher ID: I-8507-2018
Google Scholar

EDUCATION:

2011 Ph.D. in Immunology, Vita-Salute San Raffaele University, Milan (IT)

2007 European Board Certification in Internal Medicine

2001 M.D. degree, University of Milan (IT)

POSITIONS AND TRAINING:

2025 – present Professor of Pathology, Vita-Salute San Raffaele University, Milan (IT)

2023 – present Director, Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, Milan (IT)

2010 – present Group Leader, San Raffaele Scientific Institute, Milan (IT)

2007 – 2010 Postdoctoral Fellow, Harvard Medical School, Boston, MA
(Advisor: Uli von Andrian)

2002 – 2006 Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA (Advisors: Luca Guidotti and Frank Chisari)

HONORS AND AWARDS:

2025 ERC panel member for Advanced and Plus Grants LS6 “Immunity, Infection and Immunotherapy”
2024 ERC Advanced Grant (https://erc.europa.eu/apply-grant/advanced-grant)
2024 “Alessandro Moretta - Ambasciatori della Ricerca” Prize from Il Cenacolo delle Scienze e della Cultura (https://www.cenacolodellescienze.it/)
2023 ERC Proof of Concept Grant (https://erc.europa.eu/funding/proof-concept)
2021 Elected EMBO Member (https://www.embo.org/)
2020 Elected Member of the Henry Kunkel Society (https://www.henrykunkelsociety.org/)
2020 ERC panel member for Starting Grants LS6 “Immunity, Infection and Immunotherapy”
2020 ERC Proof of Concept Grant (https://erc.europa.eu/funding/proof-concept)
2017 Chiara D’Onofrio Award (http://www.fondazionechiaradonofrio.org/premi.php)
2016 ERC Consolidator Grant (https://erc.europa.eu/funding/consolidator-grants)
2016 EMBO Young Investigator Award (https://www.embo.org/funding-awards/young-investigators.html)
2015 European Association for the Study of the Liver (EASL) Emerging Leader Award (https://easl.eu/young-investigators/emerging-leader-award/)
2011 ERC Starting Grant (https://erc.europa.eu/funding/starting-grants)
2010 Armenise-Harvard Foundation Career Development Award (https://armeniseharvard.org/programs/career-development-award/)
2008 Armenise-Harvard Foundation Postdoctoral Fellowship

PROFESSIONAL ACTIVITIES:

Journal Reviewer: Nature, Science, Cell, The New England Journal of Medicine, Immunity, Nature Immunology, Nature Medicine, Nature Biotechnology, Science Immunology, Journal of Experimental Medicine, Journal of Clinical Investigation, Science Translational Medicine, Proceedings of the National Academy of Sciences, Cell Host & Microbe, Trends in Immunology, PLoS Pathogens, Hepatology, Journal of Hepatology, Gut, Gastroenterology, Journal of Immunology, Journal of Virology, European Journal of Immunology

Grant Reviewer: European Research Council (ERC), Swiss National Science Foundation (SNSF), UK Medical Research Council (MRC), Wellcome Trust, European Molecular Biology Organization (EMBO), Marie Curie Individual Fellowships, French National Research Agency (ANR), La Caixa Foundation, Israel Science Foundation, Austrian Academy of Sciences (ÖAW), Swiss Cancer League, Austrian Science Fund (FWF), Einstein Foundation Berlin, Helmholtz Association, Singapore Agency for Science, Technology & Research (A*STAR), Singapore National Medical Research Council, Canadian Institutes of Health Research.

Editorial Boards: Immunity (2026 – present), Science Immunology (2019 – present), Journal of Experimental Medicine (2023 – present), EMBO Journal (2022 – present; founding member of the Catalysts program), Trends in Immunology (2024 – present), European Journal of Immunology (Executive Committee 2022 – present; Editor-in-chief, 2025 – present), Current Opinion in Immunology (2025 – present), Liver International (2025), hLife (2023 – present), Genes & Immunity (2023 – present), Virology (2023 – present), Review Commons (2021 – present), Faculty Opinion (2021 – present).

Conference Organization: 1st International Workshop “Imaging the Immune System”, Milan, Italy (2014); International Workshop “Viral Immunity”, Milan (2016); 2nd International Workshop “Imaging the Immune System”, Rehovot, Israel (2016); 1st EMBO Sectoral Meeting on Immunology, Bergamo, Italy (2017); 3rd International Workshop “Imaging the Immune System”, Paris, France (2018); 2nd EMBO Sectoral Meeting on Immunology, Lisbon, Portugal (2018); 1st EMBO Workshop “Pathogen Immunity and Signaling”, Oxford, UK (2019); 3rd EMBO Sectoral Meeting on Immunology, Cambridge, UK (2019); Global Immunotalks (Virtual Conference Series; 2021 – present); 4th International Workshop “Imaging the Immune System” (2021, virtual); 2nd EMBO Workshop “Pathogen Immunity and Signaling”, Saint-Malo, France (2022); 20th EMBO Workshop “Germinal Centers and Immune Niches”, Rehovot, Israel (2022); 5th EMBO Workshop “Imaging the Immune System”, Lugano, Switzerland (2023); 20th International Microscopy Congress (Live Imaging of Cells, Tissues and Organisms sessions), Busan, Korea (2023); Gordon Research Conference, Immunochemistry and Immunobiology (2024, Co-Vice Chair); 3rd EMBO Workshop “Pathogen Immunity and Signaling”, San Servolo, Venice, Italy (2024); International HBV Meeting, Chicago, USA (2024); European Congress of Virology, Cavtat/Dubrovnik, Croatia (2025, Scientific Committee Member); Cell Bio 2025 (Annual Meeting of the American Society of Cell Biology), Philadelphia, PA (2025, Program Committee Member); Gordon Research Conference, Immunochemistry and Immunobiology (2026, Co-Chair); 1st Bilateral Symposium Tsinghua-San Raffaele University, Milan, Italy (2026); Cell Bio 2026 (Annual Meeting of the American Society of Cell Biology), TBD (2026, Program Committee Member); Keystone Symposium on “Tissue and Spatial Immunology”, Banff, Canada (2027, Main Organizer); European Network of Immunology Institutes (ENII) Summer School, Alghero, Italy (2027); European Congress of Immunology, Firenze, Italy (2027, Scientific Committee Member), CYTOKINES 2028 Meeting of the International Cytokine & Interferon Society (ICIS), Boston (2028, International Scientific Committee Member).

Scientific Advisory Boards: Department of Immunology, Institut Pasteur (2019); GentiBio (2023 – 2024), Pilatus Biosciences (2025 – present), InVimmune (2026 – present)

Commissions of trust: European Research Council (ERC) Panel Member for the LS6 Starting Grants (2021 – 2025) and for the Advanced and Plus Grants (2025 – present), Swiss National Science Foundation Panel Member (Division Biology and Medicine, 2023 – present; Starting Grant Panel Member, 2025 – present), ATIP-AVENIR Program (LS6 Panel Member 2018; LS6 Panel Chair 2022), Chair of the Expert Committee at HCERES for the evaluation of INSERM and CNRS units (2022), Italian Association of Immunologists (SIICA) Executive Committee (2020 – 2021 and 2024 – 2027); Reviewer for the Liver Immunology abstracts at EASL Congress (2023 – 2025); EMBO Installation Grants Committee (2023 – 2027); European Network of Immunology Institutes (ENII) Summer School Board (2025 – present).

MAJOR ADMINISTRATIVE AND INSTITUTIONAL RESPONSABILITIES:

2023 – present Director, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute
2020 – 2022 Committee for Appointments and Promotions, San Raffaele Scientific Institute
2014 – 2020 Immunology Seminar Series Organizing Committee, San Raffaele Scientific Institute
2017 – 2019 Scientific Board, PhD program in Molecular Medicine, Vita-Salute San Raffaele University
2015 – 2020 External Seminar Committee, San Raffaele Scientific Institute

CURRENT CONSULTANTSHIPS and ADVISORY BOARDS:

Gilead Sciences, Foster City, CA
BioNTech, Mainz, Germany
Curie.Bio, Boston, MA
Pilatus Biosciences, Lausanne, Switzerland
AstraZeneca, Cambrdige, UK
InVimmune, Paris, France

ACADEMIC SUPERVISION:

Technicians:
• Pietro Di Lucia (2010 – present)
• Marta Mainetti (2010 – present)
• Leonardo Giustini (2016 – present)
• Elisa Bono (2017 – present)
• Mattia Freschi (2019 – 2022; now product and sales specialist at Prodotti Gianni, Milan, Italy)
• Chiara Perucchini (2020 – present)
• Sara De Palma (2022 – present)
• Chiara Malpighi (2023 – 2025; now at Sibylla Biotech, Bresso, Italy)

Undergraduate students:
• Angelo Amabile (2010 – 2012; now Assistant Professor at Mount Sinai, NYC)
• Maurizio Vacca (2010 – 2013; now Senior Scientist at J&J)
• Gabriele Galliverti (2011 – 2013; now Senior Regulatory Writer at Novartis)
• Lucia Ganzer (2013 – 2015; now postdoc at CNR, Milan)
• Claudia Cristofani (2015 – 2017; now at Boehringer Ingelheim)
• Gianmaria Maganuco (2015 – 2018; now M.D. student at U Genova)
• Valeria Cutillo (2016 – 2019; now Medical Science Liaison at Amgen)
• Gioia Ambrosi (2017 – 2020; now M.S. student at U of Milano - Bicocca)
• Alessandra Fiore (2017 – 2019; now CFSP Assoc CRA at IQVIA Italia)
• Sara Raia (2018 – 2019; now predoc at San Raffaele, Milan)
• Eleonora Consolo (2018 – 2019; now at Sanofi-Pasteur)
• Federico Oberrauch (2018 – 2019; now M.S. student in Health Management)
• Federico De Ponti (2018 – 2020; now PhD student with Charlotte Scott at VIB, Leuven)
• Stefano Gilotto (2019 – 2020)
• Francesca Righetti (2020 – 2021; now PhD student at Uni Svizzera Italiana)
• Alessandro Lussana (2020 – 2021; now PhD student at EMBL-EBI in Cambridge, UK)
• Giulia Nosetto (2020 – 2023; now Clinical Research Associate at Ospedale San Raffaele, Milano, Italy)
• Marta Mangione (2020 – 2022; now PhD student at IFOM-IEO, Milan, Italy)
• Rosanna Santella (2021 – 2022; now Project Manager)
• Anna Celant (2022 – 2024; now PhD student with Francesca Granucci at Uni Bicocca)
• Giuliana Furiato (2022 – 2024)
• Riccardo Musi (2023)
• Valentina Sperto (2023 – 2025; now PhD student at the University of Basel, Switzerland)
• Elisa Pensieri (2024 – present)
• Alessia Manca (2024 – present)
• Fabio Tosi (2024 – present)
• Alessandro Aresu (2024 – present)
• Laura Guerra (2025 – present)
• Riccardo Visconti (2025 – present)
• Gilberto Eschillo (2025 – present)
• Amanda Bianchi (2026 – present)

Ph.D. students:
• Donato Inverso (2011 – 2016; now Group Leader and Associate Professor at San Raffaele Scientific Institute, Milan, Italy)
• Marco De Giovanni (2013 – 2019; now Group Leader and Assistant Professor at San Raffaele Scientific Institute, Milan, Italy)
• Giorgia De Simone (2016 – 2021; now Medical Science Liaison at Tillotts Pharma)
• Valeria Fumagalli (2017 – 2023; AIRC fellowship; now Assistant Professor at San Raffaele University, Milan, Italy)
• Eleonora Sala (2018 – 2023; now Project Manager at Thermo Fisher Scientific)
• Valentina Venzin (2019 – 2025; now postdoc with Yasmine Belkaid at Pasteur Institute)
• Bianca Partini (2019 – 2023; AIRC fellowship; now Scientist at HumAbs/VIR)
• Davide Marotta (2019 – present)
• Chiara Laura (2019 – 2025; now bioinformatician at Humanitas, Milano)
• Marta Grillo (2020 – present)
• Maria Nelli (2021 – present)
• Violette Mouro (2022 – present)
• Alessandro Vallorini (2024 – present)
• Francesca Silini (2024 – present)
• Francesco Iannucci (2024 – present)
• Chiara Vespari (2025 – present)

Postdoctoral fellows:
• Elena Tonti (2010 – 2012; now CSO at Adiga Life Sciences)
• Nereida Jimenez de Oya (2011 – 2016; now Principal Investigator at INIA-CSIC, Madrid)
• Stefano Sammicheli (2011 – 2016; now Senior Director @ IGI)
• Laura Sironi (2012 – 2013; now Associate Professor at University of Milano – Bicocca)
• Jessica Fioravanti (2012 – 2016; Marie Curie fellowship; now Senior Scientist at Lyell Immunopharma)
• Mirela Kuka (2013 – 2018; now Associate Professor at San Raffaele Scientific Institute and University)
• Alexandre Benechet (2015 – 2018; EMBO fellowship; now Director of Intravital Imaging, University of Lausanne)
• Diletta Magini (2016; now Senior Manufacturing Networks Lead)
• Federica Moalli (2016 – 2024; Marie-Curie fellowship; now at Charles River)
• Paola Zordan (2017 – 2020; now senior postdoc at San Raffaele)
• Vito Cucchiara (2018 – 2020; now Attending Urologist at San Raffaele)
• Francesco Andreata (2018 – 2025; Umberto Veronesi Foundation fellowship; now Assistant Professor at San Raffaele University)
• Cristian Beccaria (2018 – present; EMBO fellowship)
• Xenia Ficht (2019 – 2022; iCARE fellowship; now Staff Scientist at ETH)
• Caroline Krüger (2019 – 2022; AIRC fellowship; now Scientific Officer at Swiss National Science Foundation)
• Micol Rava’ (2019 – present)
• Elena Rodriguez Bovolenta (2020 – 2022)
• Keigo Kawashima (2021 – 2024; Uehara Memorial fellowship; Marie-Curie Fellowship)
• Pietro Delfino (2023 – present)
• Carlotta Tacconi (2023 – 2025; now Staff Scientist at San Raffaele Research Institute, Milan, Italy)
• Monica Giannotta (2023 – 2024; now Assistant Professor at University of Pavia, Italy)
• Andrea Cugurra (2023 – present)
• Caitlin Abbott (2023 – present; Marie-Curie fellowship)
• Jordan Rixon (2023 – present)
• Gonzalo Soto-Heredero (2024 – present; EMBO and Marie fellowship)
• Silja Steinmann (2025 – present)
• Mara Gelmetti (2026 – present)

Visiting Fellows:
• Florian Gärtner (2016; from LMU, Munich, Germany)
• Vo Thi My Hoa (2016; from GSK, Siena, Italy)
• Vendi Sinkovec (2017; from University of Rijeka, Croatia)
• Lisa Sandner (2021; from University of Vienna, Austria)
• Nishi Patel (2022; from University of Calgary, Canada)
• Johannes Siewert (2023; from University of Bonn, Germany)
• Veera Panova (2023; from University of Cambridge, UK)
• Riho Saito (2023; from University of Tokyo, Japan)
• Noam Shapira (2024; from Weizmann Institute, Israel)
• Natalia Stachura (2024; from Gdansk University, Poland)
• Irene Ruiz Garrido (2024; from CNIO, Madrid, Spain)
• Daphne D’Amato (2025 – present; from Niguarda Hospital, Milan)

Junior Faculty / Staff Scientists / Facility Managers:
• Mirela Kuka – Associate Professor and Project Leader
• Micol Rava’ – Facility Manager, Animal Biochemistry
• Donato Inverso – Associate Professor and Group Leader
• Valeria Fumagalli – Assistant Professor
• Marco De Giovanni – Assistant Professor and Group Leader
• Francesco Andreata – Assistant Professor
• Carlotta Tacconi – Staff Scientist

SELECTED INVITED LECTURES (LAST 3 YEARS):

2026, Mount Sinai School of Medicine, NYC (hosts: Miriam Merad and Brian Brown)
2026, Europe-Changping Laboratory T Cell Symposium (ECTS), Beijing, China
2026, 3rd Oral-Gut Conference, Rio de Janeiro, Brazil (Keynote Lecture)
2026, German Society of Immunology Annual Meeting, Munich, Germany
2026, Experimental Medicine PhD Summer School, Varenna, Italy
2026, CIMT/NIBIT Summer School, Erice, Italy
2026, Cancer Immunology Across Space and Time, Lisbon, Portugal
2026, CIML 50th Anniversary Congress, Marseille, France
2026, Paris Saclay Cancer Cluster Meeting, Paris, France
2026, Lymphocyte Antigen Receptor Signaling Meeting, Siena, Italy
2026, EASL Annual Meeting, Barcelona, Spain
2026, ImmunoMemphis, Memphis, MO, USA
2026, Aegean Conference on Innate Immunity, Crete, Greece
2026, ENII Summer School on Advanced Immunology, Alghero, Italy
2026, 112th General Meeting of the Japanese Society of Gastroenterology (JSGE), Fukui and Kanazawa, Japan (Keynote Lecture)
2026, Osaka University, Japan (host: Masaru Ishii and Shimon Sakaguchi)
2026, RIKEN, Japan (host: Sidonia Fagarasan and Tasuku Honjo)
2026, Berlin-wise Immunology Symposium 2026 (keynote lecture)
2026, Accademia Medica di Roma, Italy (host: Vincenzo Barnaba)
2026, Autoimmune liver disease days, Bari, Italy (keynote lecture)
2026, Institute for Research in Biomedicine (IRB), Bellinzona, Switzerland (host: Silvia Monticelli)
2026, Falk Symposium, Waden-Wurttemberg, Germany
2026, 5th Midwinter Conference, Seefeld, Austria
2025, RWTH University Hospital in Aachen (host: Mathias Hornef)
2025, Technical University in Munich (TUM), Germany (host: Ulrike Protzer)
2025, Cambridge University (host: Adrian Liston)
2025, Hamburg Center of Translational Immunology (host: Maura Dandri)
2025, International Symposium on Spatiotemporal Omics for Infectious Diseases 2025, Beijing, China
2025, Ping-Chih Ho’s 10-year lab anniversary symposium, Lausanne, Switzerland
2025, International Congress of Immunology IUIS 2025, Vienna, Austria
2025, 12th ANRS HBV Cure Workshop, Paris
2025, Annual Meeting of the Singaporean Society of Immunology, Singapore
2025, Antibodies and Complement: B cells, antibodies, complement functions and therapeutics, Catania, Italy
2025, ENII Summer School on Advanced Immunology, Alghero, Italy
2025, 5th Sino-German Meeting, (Immuno)Metabolism and Beyond, Oberheimbach, Germany
2025, 20th International Conference on Innate Immunity, Crete
2025, European Congress of Virology, Dubrovnik, Croatia
2025, Falk Symposium: Experimental Hepatology Days, Lyon, France (keynote)
2025, The Third Zhangyuan International Congress of Immunology, Xianyang, China
2025, Institut Curie, Paris, France (hosts: Ana-Maria Lennon-Dumenil, Sebastian Amigorena and Nicolas Manel)
2025, 11th Immunotherapy of Cancer Conference, Munich, Germany
2025, Netherlands Cancer Institute (NKI), Amsterdam
2025, The Crick Research Institute, London, UK (host: Caetano Reis e Sousa)
2025, University College London, UK (hosts: Mala Maini and Claudia Mauri)
2025, GSK Global (host: Ennio De Gregorio)
2025, SMART Symposium on Immunology, “Deconstruction and Reconstruction of Lymphocytes for Precision Medicine”, Shenzen, China
2025, Liver Seminars Day 2025, Madrid
2024, Babraham Institute’s Distinguished Lecture Series, Cambridge, UK
2024, Program in Immunology, UC San Diego, CA (host: Elina Zuniga)
2024, NOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute, La Jolla, CA (host: Susan Kaech)
2024, Champalimaud Research Symposium, Lisbon, Portugal (host: Carlos Minutti)
2024, Centre d’Immunologie de Marseille-Luminy, Marseille, France (host: Marc Bajenoff)
2024, ImmuneOctoberFest, Bridging innovation and translation in T cell immunotherapy, Munich, Germany
2024, Annual Symposium ERC Synergy ATTACK, Siena, Italy (keynote)
2024, Division of Medicine and of Gastroenterology, Perelman School of Medicine, University of Pennsylvania (host: Rebecca G. Wells)
2024, 19th Armenise-Harvard Symposium, “Visualizing biology: from the nano to the macro scale”, Boston, MA
2024, The Ragon Institute of Harvard and MIT, USA (host: Facundo Batista)
2024, Summer School, Helmholtz Centre for Infection Research, Braunschweig, Germany
2024, European Association for the Study of the Liver, ILC2024, Milan, Italy
2024, Stiftung Experimentelle Biomedizin (SEB), Zurich, Switzerland
2024, Bellinzona Institutes of Science (BIOS+), Switzerland
2024, Retreat of the University of Geneva (Pathology and Immunology Department), Annecy, France (keynote)
2024, 6th International Conference of Translational Immunology, Monopoli, Italy
2024, PhD Retreat of the Italian Association of Immunologists (SIICA), Otranto, Italy
2024, ENII Summer School of Advanced Immunology, Alghero, Italy
2024, Center for Applied Medical Research, Pamplona, Spain
2024, Keystone Symposium on Myeloid Targeting Strategies, Killarney, Ireland
2024, Annual Retreat of the San Raffaele Scientific Institute, Baveno, Italy
2024, University of Rijeka, Croatia (host: Stipan Joniic)
2024, EMBO PhD Course, Heidelberg, Germany
2024, Beyond Science Initiative, 9th Annual International Conference (keynote)
2024, Istituto Nazionale di Genetica Molecolare (INGM), Milan (host: Sergio Abrignani)
2024, SIICA Advanced School of Immunology
2024, 4th Midwinter Conference, Seefeld, Austria

PATENTS

1. Iannacone M, Alexis F, Basto P, Moseman EA, Shi J, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Immunonanotherapeutics that Provide IgG Humoral Response without T-Cell Antigen, United States Patent 8,906,381 – licensed to Selecta Biosciences

2. Shi J, Alexis F, Iannacone M, Moseman EA, Basto P, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Targeting of Antigen Presenting Cells with Immunonanotherapeutics, United States Patent 9,308,280 – licensed to Selecta Biosciences

3. Alexis F, Iannacone M, Shi J, Basto P, Moseman EA, von Andrian UH, Langer RS, Farokhzad OC, Tonti E. Adjuvant Incorporation in Immunonanotherapeutics, United States Patent 9,439,859 – licensed to Selecta Biosciences

4. Iannacone M, von Andrian UH, Farokhzad OC, Frank A, Basto P, Shi J, Moseman EA, Langer RS, Tonti E. Nicotine Immunonanotherapeutics, United States Patent 8,932,595 – licensed to Selecta Biosciences

5. Von Andrian UH, Farokhzad OC, Langer RS, Tobias J, Moseman EA, Zhang L, Basto P, Iannacone M, Alexis F. Vaccine Nanotechnology, United States Patent 9,539,210 – licensed to Selecta Biosciences

6. Von Andrian UH, Iannacone M, Tonti E, Moseman EA. Vaccines Comprising Bisphosphonates and Methods of Use Thereof, United States Patent 10,188,733

7. Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Inhibitors of Hepatitis B Virus, WO2020/016427 - discontinued

8. Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Cyclic Inhibitors of Hepatitis B Virus, WO2020/016434 – discontinued

9. Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Ferrara M, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Tricyclic Inhibitors of Hepatitis B Virus (I), WO2020/030781

10. De Francesco R, Donnici L, Guidotti LG, Iannacone M, Bencheva LI, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Di Fabio R, Summa V. Oxalamido-substituted Tricyclic Inhibitors of Hepatitis B Virus (I), WO2020/234483

11. Iannacone M, Guidotti LG, Naldini L, Cantore A, Ostuni R. Agents and methods for treating viral infections, WO2020/239964

12. Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Ferrara M, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Spirocyclic inhibitors of hepatitis B virus. WO2021/160617

13. Iannacone M, Guidotti LG. Agents and methods for increasing liver immune response. UK Patent Application 2018657.3 – discontinued

14. Guidotti LG, Iannacone M, De Francesco R, Summa V, Cannalire R, Donnici L. MACROCYCLIC PEPTIDOMIMETICS AS ANTIVIRAL AGENTS. European patent application N. 24192298.8

15. Di Fabio R, Iannacone M, Guidotti LG, De Francesco R. INIBITORI DI INGRESSO DELL'HBV E/O DELL'HDV. Italian patent application N. 102025000023311

16. Iannacone M, Guidotti LG, Pardi N, Andreata F. IL2 Gene Therapy – LNP Delivery. US patent application 63/985,370

PUBLICATIONS (Total citations > 16500; H-index > 60)

1. Gabandé-Rodriguez E, Soto-Heredero G, Carrasco E, Anerillas C, Martinez-Cano J, Escrig-Larena JI, Delgado-Pulido S, Francos-Quijorna I, Desdin-Micó G, Smirnova T, Gomez de las Heras MM, Fernandez-Almeida A, Leandri A, Cugurra A, Blanco EM, Winand-Osete E, Zorita V, Bean C, Basset V, Solly F, Garrido A, de Cabo R, Mañes S, Pasparakis M, Iannacone M, Cobaleda C, Naveiras O, Gorospe M, Mittelbrunn M (2026) Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing myelopoiesis. Submitted

2. Razafiarison J, Alzaid F, Leveau C, Tonui D, Diedisheim M, Bied M, Silvin A, Kong Wt, Anagnostopoulos G, Laveille A, Dunsmore G, Signolle N, Hammoutene A, Laura C, Garica-Manteiga JM, Andreata F, Ficht X, Weidner D, Guo W, Boissonnas A, Greter M, Liu Z, Chakarov S, Uderhardt S, Paradis V, Iannacone M, Venteclef N, Ginhoux F, Bleriot C (2026) CD36+ Kupffer cells control postprandial lipid clearance and fuel metabolic dysfunction-associated steatotic liver diseases. Submitted

3. Nannoni M, Muggeo S, Ruffini G, Behrens T, Cugurra A, Iannacone M, Broccoli V (2026) Microglia depletion dampens neurodegenration caused by astroglial selective a-Synuclein accumulation by promoting a macrophage neuroprotective state. Submitted

4. Tacconi C, Partini B, Delfino P, Laura C, Giannotta M, Beccaria CG, Di Lucia P, D’Antonio M, Ficht X, De Paulis C, Taranto D, Ambrosi G, Nosetto G, Rossari F, Fioravanti J, Fumagalli V, Abbott C, Marotta D, Bono EB, Giustini L, Ravà M, Perucchini C, Pedica F, Canu T, Russo T, Raimondi A, Santangelo D, Hamon P, De Giovanni M, Garbi N, De Cobelli F, Esposito A, Ponzoni M, Cantore A, Naldini L, Lugli E, Akkari L, Casadei-Gardini A, Merad M, Guidotti LG, Inverso D, Moalli F, Iannacone M (2026) Tumor size-dependent endothelial switch restricts CD8+ T cell surveillance of liver cancer. Submitted

5. Bhat GP, Diprima S, Beccaria CG, Podini P, Badaloni A, Motta A, Brambilla I, Boselli D, Gentile F, Fabbrizio P, Nardo G, Bendotti C, de Pretis S, Riva N, Iannacone M*, Quattrini A*, Bonanomi D* (2026) Early endothelial activation at the blood-nerve barrier defines a hallmark of ALS. Submitted (*co-senior authors)

6. Park J, Chuang Y-M, Chun Theng Chong P, Garnica Casparros J, Ye C-H, Benechet AP, Fumagalli V, Lindblad KE, Iannacone M, Lujambio A, Carmona SJ, Yu S-H, Ho P-C (2026) Kupffer cell-mediated intrahepatic T cell priming diversifies T cell differentiation and boosts anti-tumor immunity in hepatocellular carcinomas. Submitted

7. D’Uonnolo G, Ranucci S, Tacconi C, Ravà M, Inverso D, Guidotti LG, Iannacone M, De Giovanni M (2026) Tracking recently recruited immune cells via two-pulse intravascular labeling unlocks discovery of tumor-entry determinants. Submitted

8. Gallo G, Donnici L, Carneiro S, Colley LS, Loffreda A, Fumagalli V, Iannacone M, Mazza D, Merckel O, Incarnato D, De Francesco R, Monteleone E, De Magis A, Bianchi ME (2026) Therapeutic potential of LNA-ASOs targeting conserved single-stranded regions in SARS-CoV-2 variants. Submitted

9. Marotta D, Perucchini C, Grillo M, Fumagalli V, Di Lucia P, Ravà M, Giustini L, Malphighi C, D’Uonnolo G, Rixon J, Mouro V, Abbott C, Stachura N, Andreata F, Donnici L, Scavone M, Inverso D, De Francesco R, Gaya M, Ruggeri ZM, Podda G, Guidotti LG, Iannacone M#, De Giovanni M# (2026) Platelet-derived serotonin drives age-related pathology in SARS-CoV-2 infection. Submitted (#co-last and co-corresponding authors)

10. Giacca G, Buccarello G, Bresesti C, Breggion S, Notaro M, Russo S, D’Alessio F, Chiaro J, Branca RMM, Shrung KR, Lehtiö J, Monti M, Trippitelli F, Potenza A, Ruggiero E, Andreata F, Rancoita PMV, Iannacone M, Bonini C, Naldini L, Cerullo V, Squadrito M.L. (2026) Circulating tumor antigens drive immune suppression and disease progression. Submitted

11. Pesce E, Donnici L, Patrone M, Fumagalli V, Garavaglia C, Colombo B, Manganaro L, Consonni M, Ramia E, Bono EB, Perucchini C, Iannacone M, Corti A, Curnis F, De Francesco R, Dellabona P, Grifantini R, Degano M, Casorati G, Arbore G (2026) Inhalable catalytically-inactive ACE2-Fc decoy prevents SARS-CoV-2 infection in mice. Submitted

12. Manenti S, Croese T, Finardi A, Mandelli A, Pedrini E, Marostica G, Bottoni A, Zhong X, Waisman A, Borsellino G, Battistini L, Bacigaluppi M, Gullotta G, Moiola L, Genchi A, Iannacone M, Ostuni R, Liu Q, Absinta M, Schwartz M, Cassatella MA, Scapini P, Magliozzi R, Martino G, Rocca MA, Furlan R (2026) PD-L2 expressing neutrophils are key players in regulating autoimmune neuroinflammation. Submitted

13. Sarker G, Habermann E, Chandran A, Monfeuga T, Maroteau C, Lundh S, Sidarta-Oliveira, Raimondi A, Ziegler K, Gomes T, Cordeiro T, Parekh K, Schmid E, Sanmartin Fernandez P, Martinez Sanchez N, Arus B, Cheung W, Zhu Y, Shaked M, Knowles SCL, Engelhardt SH, Iannacone M, Scherer PE, Lopez M, Toledo EM, Domingos A (2026) The perineurium integrates leptin with its sympathetic outflow to protect against obesity. Submitted

14. Swadling L, Fumagalli V, Maini MK, Iannacone M (2026) Abortive infection: T Cells as Early, Antibody-Independent Defenders. Nature Reviews Immunology, submitted (invited review)

15. Araujo David B, Andreata F, Bleriot C, Ginhoux F, Kubes P, Iannacone M (2026) Kupffer cells in liver health and disease: guardians of metabolism, immunity, and beyond. Nature Reviews Immunology, in press

16. Altenburger LM, Claudino Carvoeiro DC, Dehio P, Zhou J, Laura C, Bofi i Cuadros A, Katoch M, Krüger C, Barreto de Albuquerque J, Pfenninger P, Martinez Magdaleno J, Bofi I Cuadros A, Mehling M, Iannacone M, Gheinani H, Dengjel J, Abe J, Stein JV (2026) A lymphoid tissue chemokine checkpoint prevents loss of CD8+ T cell functionality. Science, in press

17. Kusch C, Stegner D, Weiss LJ, Nurden P, Burkard P, Johnson D, Bergmeier W, Onursal C, Navarro S, Hackenbroch C, Pfeiffer D, Bonfiglio SI, Meub M, Gross C, Schenk J, Fumagalli V, Mott K, Bender M, Iannacone M, Andres O, Kastenmüller W, Heinze KG, Sauer M, Schulze H, Ley K, Nurden AT, Nieswandt B (2026) Platelet-derived integrin and tetraspanin-enriched tethers exacerbate severe inflammation. Science, 391:eadu2825

18. Abbott C, Mouro V, Perucchini C, Vespari C, Iannacone M (2025) Optimizing recovery of hepatic regulatory T cells: a practical guide using ARTC2 blockade. European Journal of Immunology, 55:e70095

19. Pizzagalli DU, …, Iannacone M, … Gonzalez SF (2025) Systematic analysis of immune cell motility leveraging the open intravital microscopy database Immunemap. The EMBO Journal, in press

20. Venzin V, Iannacone M (2025) Reframing IL-27: A central regulator of CD8+ T cell immunity. Trends in Immunology, in press (artwork selected for the cover)

21. Masopust D, …., Iannacone M, … Ahmed R (2025) Guidelines for T cell nomenclature. Nature Reviews Immunology, in press

22. Panetti C, Dätwyler R, Moncsek A, Patikas N, Agrafiotis A, Tang A, Andreata F, Fumagalli V, De Lima J, King CG, Vasanthakumar A, Iannacone M, Kallies A, Yermanos A, Hemberg M, Joller N (2025) The co-inhibitory receptor TIGIT promotes tissue protective functions in T cells. Nature Immunology, 26:2074

23. De Giovanni M, Inverso D, Iannacone M (2025) From histology to high-resolution mapping: the rise of spatial omics in immunology. European Journal of Immunology, 55:e70073

24. Guillaume SM, Beccaria CG, Iannacone M#, Linterman MA# (2025) Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers. Immunological Reviews, 335(1):e70063 (#co-senior authors)

25. Milani M, Starinieri F, Beretta S, Canepari C, Monti M, Zambrano S, Mazza D, Fabiano A, Simoni C, Cammarota E, Volpin M, Bortolussi G, Russo F, Biffi M, Genua M, Ostuni R, Muro AF, Montini E, Moalli F, Iannacone M, Merelli I, Cantore A (2025) Spatiotemporal liver dynamics shapes hepatocellular heterogeneity and impacts in vivo gene engineering. Journal of Hepatology, in press

26. Iannacone M, Beccaria CG, Allweiss L, Lucifora J, Tavis JE, Gehring AJ, Dandri M (2025) Targeting HBV with RNA interference: mechanisms, challenges and paths to cure. Science Translational Medicine, 17:eadv3678

27. Venzin V, Beccaria CG, Perucchini C, Delfino P, Bono E, Giustini L, Moalli F, Fumagalli V, Grillo M, Laura C, Di Lucia P, Reinhard K, Petschenka J, Omokoko TA, Ottolini S, Celant A, Kawashima K, Ravà M, De Giovanni M, Inverso D, Kuka M, Kennedy PTF, Guilliams M, Casorati G, Şahin U, Le Bert N, Bertoletti A, Vascotto F, Guidotti LG, Iannacone M (2025) CD4+ T cells license Kupffer cells to reverse the CD8+ T cell dysfunction induced by hepatocellular priming. Nature Immunology, 26:1352 (artwork selected for the cover)

28. Pfister M, …., Iannacone M (as part as the Consensus4pCCA Collaborative), …., Clavien P-A (2025) Recommendations on Perihilar Cholangiocarcinoma. The Milan Jury-Based Consensus. Annals of Surgery, doi: 10.1097/SLA.0000000000006773

29. Sala E, Nelli M, Laura C, Di Lucia P, Beccaria CG, Bono EB, Mangione M, Marotta D, Sperto V, Grillo M, Giustini L, Tosi F, Nie J, Kim D, Furiato G, Malpighi C, Consolo E, Becher B, David E, Cohen M, Giladi A, Amit I, Bosselut R, Guidotti LG, Iannacone M#, Kuka M# (2025) T cell-derived IFN- suppresses T follicular helper cell differentiation and antibody responses. The EMBO Journal, 44:2400 (#co-last and co-corresponding authors)

30. Iannacone M, Bakocevic N (2025) Striking the Right Chord at EJI: Introducing Editor-in-Chief Matteo Iannacone and the Seamless Transfer Policy. European Journal of Immunology, 55:e202551784

31. Fumagalli V, Iannacone M (2025) Unlocking CD8+ T cell potential in chronic HBV infection. Nature Reviews Gastroenterology & Hepatology, 22:92

32. De Giovanni M, Inverso D, Iannacone M (2024) Understanding local immunity to enable regionalized medicine. The EMBO Journal, 43:5788

33. Thimme R, Bertoletti A, Iannacone M (2024) Beyond exhaustion: the unique characteristics of CD8+ T cell dysfunction in chronic HBV infection. Nature Reviews Immunology, 24:775

34. Baldwin JG, Heuser C, Saha T, Schelker R, Slavkovic-Lukic D, Strieder N, Barden M, Mastrogiovanni F, Martin-Santos A, Raimondi A, Brohawn P, Higgs BW, Gebhar C, Kapoor V, Telford WG, Robey PG, Gautam S, Iannacone M, Inverso D, Rehli M, Fioravanti J, Sengupta S, Gattinoni L (2024) Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy. Cell, 187:6614

35. Stark K, Kilani B, Stockhausen S, Busse J, Schubert I, Tran T-D, Gaertner F, Leunig A, Pekayvaz K, Nicolai L, Fumagalli V, Stermann J, Stephan F, David C, Müller MB, Heyman B, Lux A, da Palma Guerreiro A, Frenzel LP, Schmidt CQ, Dopler A, Moser M, Chandraratne S, von Brühl M-L, Lorenz M, Korff T, Rudelius M, Popp O, Kirchner M, Mertins P, de Boer OJ, van der Wal AC, Nimmerjahn F, Iannacone M, Sperandio M, Engelmann B, Verschoor A, Massberg S (2024) Antibodies and complement are key drivers of thrombosis. Immunity, 57:2140

36. Andreata F, Iannacone M (2024) The hidden strength of CD8+ T cells in chronic hepatitis B. Nature Immunology, 25:1515

37. Pallavicini I, Frasconi T, Catozzi C, Ceccaci E, Tiberti S, Hass D, Samson J, Heuser-Loy C, Nava Lauson CB, Mangione M, Preto E, Bigogno A, Sala E, Iannacone M, Mercurio C, Gattinoni L, Caruana I, Kuka M, Nezi L, Minucci S, Manzo T (2024) LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness. Nature Communications, 15:7366

38. Kakogiannos N, Scalise AA, Martini E, Maderna C, Benvenuto AF, D’Antonio M, Carmignani L, Magni S, Gullotta GS, Lampugnani MG, Iannelli F, Beznoussenko GV, Mironov AA, Cerutti C, Bentley K, Philippides A, Zanardi F, Bacigaluppi M, Sigismund S, Bassani C, Farina C, Martino G, Dejana E, Iannacone M#, Inverso D#,, Giannotta M#, (2024) Gpr126 is a crucial regulator of blood-brain barrier maturation and function. Journal of Clinical Investigation, 134:e165368 (#co-last authors) (artwork selected for the cover)

39. Venzin V, Beccaria CG, Andreata F, Fumagalli V, Iannacone M (2024) Intrahepatic immunity to hepatitis B virus. Journal of Hepatology, in press

40. Gyrd-Hansen M, Kajaste-Rudnitski A, Manel N, Rehwinkel J, van der Veen AG, Iannacone M (2024) Advancements in Pathogen Immunity and Signaling. Nature Immunology, 25:1322

41. Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, van den Heuvel D, Guo G, Belz L, Sobirova G, Zhang Z, Titova A, Martinez Navarro A, Pekayvaz K, Lorenz M, von Baumgarten L, Straub T, Popper B, Zheden V, Kaufmann W, von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Broker T, Walzog B, Scheiermann C, Aird W,Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt M, Hauschild R, Rudelius M, Oostendrop RAJ, Iannacone M, Heinig M, Massberg S (2024) Plasmacytoid dendritic cells regulate tissue homeostasis of megakaryocytes. Nature, 631:645

42. Andreata F, Krueger CC, Laura C, Ravà M, Ficht X, Kawashima K, Beccaria CG, Moalli F, Partini B, Fumagalli V, Nosetto G, Di Lucia P, Montali I, Garcia-Manteiga JM, Bono EB, Giustini L, Perucchini C, Venzin V, Ranucci S, Inverso D, De Giovanni M, Genua M, Ostuni R, Lugli E, Isogawa M, Ferrari C, Boni C, Fisicaro P, Guidotti LG, Iannacone M (2024) Therapeutic potential of co-signaling receptor modulation in hepatitis B. Cell, 187:4078

43. HBV2023, Allweiss L, Cohen C, Dias J, Fumagalli V, Guo H, Harris JM, Hu J, Iannacone M, Isogawa M, Jeng W-J, Kim K-H, Kramvis A, Li W, Lucifora J, Muramatsu M, Neuveut C, Ploss A, Pollicino T, Protzer U, Tan A, Tanaka Y, Tu T, Tsukuda S, Thimme R, Urban S, Watashi K, Yuan Z, Yeh S-H, McKeating JA, Revill PA (2024) Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus. Journal of General Virology, 105:001978

44. Mooney AH, Draper SL, Burn OK, Andreson RJ, Compton BJ, Tang C, Farrand KJ, Di Lucia P, Ravà M, Fumagalli V, Giustini L, Bono E, Godfrey DI, Heath WR, Yuan W, Chisari FV, Guidotti LG, Iannacone M, Sidney J, Sette A, Gulab S, Painter GF, Hermans IF (2024) Preclinical evaluation of therapeutic peptide-glycolipid conjugate vaccines for chronic hepatitis B virus that stimulate antiviral activities of T cells and NKT cells. JHEP Reports, 6:101038

45. Fumagalli V, Ravà M, Marotta D, Di Lucia P, Bono EB, Giustini L, De Leo F, Casalgrandi M, Monteleone E, Mouro V, Malpighi C, Perucchini C, Grillo M, De Palma S, Donnici L, Marchese S, Conti M, Muramatsu H, Perlman S, Pardi N, Kuka M, De Francesco R, Bianchi ME, Guidotti LG, Iannacone M (2024) Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination. Nature Immunology, 25:633

46. Kawashima K, Andreata F, Beccaria CG, Iannacone M (2024) Priming and maintenance of adaptive immunity in the liver. Annual Review of Immunology, 42:375

47. Ng MSF, Kwok I, Tan L, Shi C, Cerezo-Wallis D, Tan Y, Leong K, Calvo GF, Yang K, Zhang Y, Jing J, Liong KH, Wu D, He R, Liu D, Teh YC, Bleriot C, Caronni N, Moalli F, Liu Z, Duan K, Narang V, Ballesteros I, Li M, Chen J, Liu Y, Liu L, Qi J, Liu Y, Jiang L, Shen B, Cheng H, Cheng T, Angeli V, Sharma A, Loh Y-H, Tey HL, Chong SH, Iannacone M, Ostuni R, Hidalgo A, Ginhoux F, Ng LG (2024) Deterministic reprogramming of neutrophils within tumors. Science, 383:eadf6493

48. Andreata F, Moynihan KD, Fumagalli V, Di Lucia P, Pappas DC, Kawashima K, Ni I, Bessette PH, Perucchini C, Bono E, Giustini L, Nguyen HC, Chin SM, Yeung YA, Gibbs CS, Djuretic I, Iannacone M (2024) CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus. Science Translational Medicine, 16:eadi1572 (artwork selected for the cover)

49. Mazzarella L, Santoro F, Ravasio R, Fumagalli V, Massa PE, Rodighiero S, Gavilan E, Romanenghi M, Achutti Duso B, Bonetti E, Manganaro L, Pallavi R, Trastulli D, Pallavicini I, Gentile C, Monzani S, Leonardi T, Pasqualato S, Buttinelli G, Di Martino A, Fedele G, Schiavoni I, Stefanelli P, Meroni G, De Francesco R, Steinkuhler C, Fossati G, Iannacone M, Minucci S, Pelicci PG (2023) The lysine demethylase LSD1 controls the balance between inflammatory and antivral responses against coronaviruses. Science Signaling, 16:eade0326

50. Haberman ER, Sarker G, Arus BA, Ziegler KA, Meunier S, Martinez-Sanchez N, Freibergerova E, Yilmaz-Özcan S, Fernandez-Gonzalez I, Zentai C, O’Brien CJO, Grainger DE, Sidarta-Oliveira D, Chakarov S, Raimondi A, Iannacone M, Engelhardt S, Lopez M, Ginhoux F, Domingos AI (2023) Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis. Immunity, 57:141

51. Fumagalli V, Iannacone M (2024) The interplay of drug therapeutics and immune responses to SARS-CoV-2. Cellular and Molecular Immunology, 21:197

52. Caronni N, La Terza F, Vittoria FM, Barbiera G, Mezzanzanica L, Cuzzola V, Barresi S, Pellegatta M, Canevazzi P, Dunsmore G, Leonardi C, Montaldo E, Lusito E, Dugnani E, Citro E, Ng MSF, Lena MS, Drago D, Andolfo A, Mortellaro A, Corbo V, Mondino A, Dellabona P, Piemonti L, Taveggia C, Doglioni C, Cappello P, Novelli F, Iannacone M, Ng LG, Ginhoux F, Crippa S, Falconi M, Bonini C, Naldini L, Genua M, Ostuni R (2023) IL-1+ macrophages fuel pathogenic inflammation in pancreatic cancer. Nature, 623:415

53. Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Di Lascio G, Tamburini S, Caproni E, Coria L, Ravà M, Fumagalli V, Di Lucia P, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G (2023) Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine. Vaccines, 11:1546

54. Fiore A, Sala E, Laura C, Riba M, Fumagalli V, Nelli M, Mangione M, Provero P, Oberrauch F, Cristofani C, Iannacone M, Kuka M (2023) A fluorescent reporter model for the visualization and characterization of TDC. European Journal of Immunology, e2350529

55. Sandner L, Alteneder M, Rica R, Woller B, Sala E, Frey T, Tosevska A, Zhu C, Madern M, Khan M, Hoffmann P, Schebesta A, Taniuchi I, Bonelli M, Schmetterer K, Iannacone M, Kuka M, Ellmeier W, Sakaguchi S, Herbst R, Boucheron N (2023) The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling. Journal of Experimental Medicine, 220:e20221466

56. Fumagalli V, Di Lucia P, Ravà M, Marotta D, Bono E, Grassi S, Donnici L, Cannalire R, Stefanelli I, Ferraro A, Esposito F, Pariani E, Inverso D, Delbue S, Tramontano E, De Francesco R, Summa V, Guidotti LG, Iannacone M (2023) Nirmatrelvir treatment of SARS-CoV-2 infected mice blunts antiviral adaptive immune responses. EMBO Molecular Medicine, 15:e17580

57. Stoler-Barak L, Harris E, Peres A, Hezroni H, Kuka M, Di Lucia P, Grenov A, Gurwicz N, Kupervaser M, Yip BH, Iannacone M, Yaari G, Crispino JD, Shulman Z (2023) B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation. Nature Communications, 14:1462

58. Gioia U, Tavella S, Martinez Orellana P, Cicio G, Colliva A, Paldino A, Ceccon M, Cabrini M, Henriques AC, Fumagalli V, Paladino A, Presot E, Rajasekharan S, Iacomino N, Pisati F, Matti V, Sepe S, Conte M, Barozzi S, Lavagnino Z, Carletti T, Volpe MC, Cavalcante P, Iannacone M, Rampazzo C, Bussani R, Tripodo C, Zacchigna S, Marcello A, d’Adda di Fagagna F (2023) SARS-CoV-2 infection causes DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence. Nature Cell Biology, 25:550

59. Scherer S, Oberle SG, Kanev K, Gerullis AK, Wu M, de Almeida GP, Puleston DJ, Baixauli F, Aly L, Greco A, Nizharadze T, Becker NB, Hoesslin MV, Donhauser LV, Berner J, Chu T, McNamara HA, Esencan Z, Roelli P, Wurmser C, Kleiter I, Vehreschild MJGT, Mayer CA, Knolle P, Klingenspor M, Fumagalli V, Iannacone M, Prlic M, Korn T, Pearce EL, Höfer T, Schulz AM, Zehn D (2023) Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T-cell development. Nature Immunology, 24:501

60. Epis S, Varotto-Boccazzi I, Manenti A, Rubolini D, Gabrieli P, Cattaneo GM, Gourlay L, Dapporto F, Monti M, Razzano I, Leonardi M, Iannacone M, Recordati C, Bertola L, Fiorina P, Marvasi L, Montomoli E, Zuccotti GV, Bandi C (2022) Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of LeCoVax-2, a candidate vaccine against COVID-19. Pharmacological Research, 186:106546

61. Compagnone M, Pinto E, Salvatori E, Lione L, Conforti A, Marchese S, Ravà M, Ryan K, Hall Y, Rayner E, Salguero J, Paterson J, Iannacone M, De Francesco R, Aurisicchio L*, Palombo F* (2022) DNA-vaccine-induced immune response correlates with lower viral SARS-CoV-2 titers in a ferret model. Vaccines, 10:1178 (*co-last authors)

62. Ivanova Bencheva L, Donnici L, Ferrante L, Prandi A, Sinisi R, De Matteo M, Randazzo P, Conti M, Di Lucia P, Bono E, Giustini L, Orsale MV, Patsilinakos A, Monteagudo E, Iannacone M, Summa V, Guidotti LG, De Francesco R, Di Fabio R (2022) Discovery and antiviral profile of new sulfamoylbenzamide derivative as HBV capsid assembly modulators. Bioorganic & Medicinal Chemistry Letters, 73:128904

63. Iannacone M, Bleriot C, Andreata F, Ficht X, Laura C, Garcia-Manteiga JM, Uderhardt S, Ginhoux F (2022) Response to contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells. Immunity, 55:1141

64. Bertoletti A, Iannacone M (2022) Editorial overview: Viral pathogenesis. Current Opinion in Virology, 55:101253 (invited editorial for a section on SARS-CoV-2)

65. Alvisi G, Termanini A, Soldani C, Portale F, Carriero R, Pilipow K, Polidoro M, Franceschini B, Malenica I, Puccio S, Lise V, Galletti G, Zanon V, Colombo FS, Tufano M, Peano C, Iannacone M, Roychoudhuri R, Donadon M, Torzilli G, Kunderfranco P, Di Mitri D, Lugli E, Lleo A (2022) Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as potential therapeutic target. Journal of Hepatology, 77:1359

66. Barreto de Albuquerque J, Altenburger LM, Abe J, von Werdt D, Wissmann S, Magdaleno JM, Francisco D, van Geest G, Ficht X, Iannacone M, Bruggmann R, Müller C*, Stein JV* (2022) Microbial uptake in oral mucosa-draining lymph nodes leads to rapid release of cytotoxic CD8+ T cells lacking a gut-homing phenotype. Science Immunology, 7:eabf1861 (*co-last authors)

67. Iannacone M, Andreata F, Guidotti LG (2022) Immunological insights in the treatment of chronic hepatitis B. Current Opinion in Immunology, 77:102207

68. Nicolai L, Leunig A, Pekayvaz K, Esefeld M, Anjum A, Rath J, Riedlinger E, Ehreiser V, Mader M, Eivers L, Hoffknecht M-L, Zhang Z, Kugelmann, Rossaro D, Escaig R, Kaiser R, Polewka V, Titova A, Petzold T, Spiekermann K, Iannacone M, Thiele T, Greinacher A, Stark K, Massberg S (2022) Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration. Blood, 140:478

69. Iannacone M, Guidotti LG (2022) Developing a cure for chronic hepatitis B requires a fresh approach. Nature, 603:S49

70. Konjar Š*, Ficht X*, Iannacone M#, Veldhoen M# (2022) Heterogeneity of tissue resident memory T cells. Immunology Letters, 245:1 (*co-first authors; #co-last authors)

71. Cohen M, Giladi A, Barboy O, Hamon P, Li B, Zada M, Gurevich-Shapiro A, Beccaria C, David E, Maier B, Buckup M, Kamer I, Deczkowska A, Le Berichel J, Bar J, Iannacone M, Tanay A#, Merad M#, Amit I# (2022) The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response. Nature Cancer, 3:303 (#co-last authors)

72. Fumagalli V, Venzin V, Di Lucia P, Moalli F, Ficht X, Ambrosi G, Giustini L, Andreata F, Grillo M, Magini D, Ravà M, Friedrich C, Fontenot JD, Bousso P, Gasteiger G, Vivier E, Kuka M, Guidotti LG, Iannacone M (2022) Group 1 ILCs regulate T cell-mediated liver immunopathology by controlling local IL-2 availability. Science Immunology, 7:eabi6112

73. Pekayvaz K, Leunig A, Kaiser R, Brambs S, Joppich M, Janjic A, Popp O, Nixdorf D, Fumagalli V, Schmidt N, Polewka V, Anjum A, Knottenberg V, Eivers L, Wange LE, Gold C, Kirchner M, Muenchhoff M, Hellmuth JC, Scherer C, Rubio-Acero R, Eser T, Deak F, Kuhl N, Linder A, Saar K, Tomas L, Schulz C, Wiser A, Enard W, Kroidl I, Geldmacher C, von Bergwelt-Baildon M, Keppler OT, Munschauer M, Iannacone M, Zimmer R, Mertins P, Hubner N, Hölscher M, Massberg S, Stark K, Nicolai L (2022) Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection. Nature Communications, 13:1018

74. Aiolfi R*, Sitia G*, Iannacone M*, Brunetta I, Guidotti LG, Ruggeri ZM (2022) Arenaviral infection causes bleeding in mice due to reduced serotonin release from platelets. Science Signaling, 15:eabb0384 (*co-first authors)

75. Cossarizza A, …, Iannacone M., …, Yang J (2021) Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition). European Journal of Immunology, 51:2708

76. Fumagalli V, Ravà M, Marotta D, Di Lucia P, Laura C, Sala E, Grillo M, Bono E, Giustini L, Perucchini C, Mainetti M, Sessa A, Garcia-Manteiga JM, Donnici L, Manganaro L, Delbue S, Broccoli V, De Francesco R, D’Adamo P, Kuka M, Guidotti LG, Iannacone M (2022) Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion. Science Immunology, 7:eabl9929

77. Kuka M, Iannacone M (2022) Heterogeneity in antiviral B cell responses: lessons from the movies. Immunological Reviews, 306:224

78. Andreata F, De Simone G, Fumagalli V, Di Lucia P, Ficht X, Beccaria CG, Bleriot C, Kuka M, Ginhoux F, Iannacone M (2021) Isolation of mouse Kupffer cells for phenotypic and functional studies. STAR Protocols, 2:100831

79. Fedeli M, Kuka M, Finardi A, Albano F, Viganò V, Olson EN, Iannacone M, Furlan R, Dellabona P#, Casorati G# (2021) miR-21 sustains CD28-signaling and facilitates low affinity T-cell responses at the expense of self-tolerance. Clinical and Translational Immunology, 10:e1321 (#co-last authors)

80. Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D’Acunto E, Chiarini V, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G, Criscuolo E, Clementi N, Mancini N, Groß R, Seidel A, Wettstein L, Münch J, Donnici L, Conti M, De Francesco R, Kuka M, Ciliberto G, Castilletti C, Capobianchi MR, Ippolito G, Guidotti LG, Rovati L, Iannacone M#, Aurisicchio L# (2021) COVID-eVax, an electroporated plasmid DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain, elicits protective immune responses in animal models of COVID-19. Molecular Therapy, 29:1 (#co-last and co-corresponding authors)

81. Tuzlak S, Dejean A, Iannacone M, Quintana F, Waisman A, Ginhoux F, Korn T, Becher B (2021) Repositioning Th cell polarization from single cytokines to complex help. Nature Immunology, 22:1210

82. Bleriot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, De Simone G, Andreata F, Fumagalli V, Guo W, Wan G, Gessain G, Khalilnezhad A, Zhang X-M, Ang N, Shen P, Morgantini C, Azzimato V, Kong WT, Liu Z, Pai R, Lum J, Shihui F, Low I, Xu C, Malleret B, Kairi MFM, Balachander A, Cexus O, Larbi A, Lee B, Newell E, Ng LG, Phoo WW, Sobota RM, Sharma A, Howland SW, Chen J, Bajenoff M, Yvan-Charvet L, Venteclef N, Iannacone M, Aouadi M, Ginhoux F (2021) Identification of two subsets of Kupffer cells with distinct functions in liver metabolism. Immunity, 54:2101

83. De Simone G, Andreata F, Bleriot C, Fumagalli V, Laura C, Garcia-Manteiga JM, Di Lucia P, Gilotto S, Ficht X, Bono EB, Giustini L, De Ponti F, Ambrosi G, Mainetti M, Zordan P, Benechet AP, Ravà M, Chakarov S, Moalli F, Bajenoff M, Guidotti LG, Ginhoux F, Iannacone M (2021) Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming. Immunity, 54:2089 (artwork selected for the cover)

84. Cilenti F, Barbiera G, Caronni N, Iodice D, Barresi S, Montaldo E, Lusito E, Miotto P, Di Lucia P, Lazarevic D, Cirillo D, Iannacone M, Genua M#, Ostuni R# (2021) A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression. Immunity, 54:1665 (#co-last authors)

85. Iannacone M and Guidotti LG (2022) Immunobiology and pathogenesis of hepatitis B virus infection. Nature Reviews Immunology, 22:19

86. Baudi I, Isogawa M, Moalli F, Onishi M, Kawashima K, Ito H, Ishikawa T, Wakita T, Iannacone M, Tanaka Y (2021) Type I IFN signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen. PLoS Pathogens, 17:e1009228

87. Perro M, Iannacone M, von Andrian UH, Peixoto A (2020) Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection. Virulence, 11:1640

88. Ficht X and Iannacone M (2020) Immune surveillance of the liver by T cells. Science Immunology, 5:eaba2351

89. Fumagalli V, Di Lucia P, Venzin V, Bono E, Jordan R, Frey C, Delaney W, Chisari FV, Guidotti LG, Iannacone M (2020) Antibody-mediated clearance of serum HBsAg has minimal impact on CD8+ T cell responses in mouse models of HBV pathogenesis. Journal of Experimental Medicine, 217:e20200298

90. Stolp B, Thelen F, Ficht X, Altenburger LM, Ruef N, Inavalli VVGK, Germann P, Page N, Moalli F, Raimondi A, Keyser K, Seyed Jafari SM, Barone F, Dettmer MS, Merkler D, Iannacone M, Sharpe J, Schlapbach C, Fackler OT, Nägerl UV, Stein JV (2020) Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance. Science Immunology, 5:eaaz4371

91. De Giovanni M, Cutillo V, Giladi A, Maganuco CG, Medaglia C, Bono E, Di Lucia P, Giustini L, Cristofani C, Pinschewer DD, Kastenmuller W, Amit I, Kuka M, Iannacone M (2020) Spatiotemporal regulation of type I interferon expression determines antiviral CD4+ T cell polarization. Nature Immunology, 21:321

92. De Simone G, Mazza EMC, Cassotta A, Davydov A, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Ferrari F, Orrù V, Fiorillo E, Iannacone M*, Chudakov DM*, Sallusto F*, Lugli E (2019) CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential. Journal of Immunology, 203:3179 (*equal contribution)

93. Benechet AP, De Simone G, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Moalli F, Lusito E, Fumagalli V, Bianchessi V, Zordan P, Bono E, Giustini L, Bonilla WD, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R, Guidotti LG, Iannacone M (2019) Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming. Nature, 574:200. Awarded with the 2019 Best Publication in Hepatology by the Italian Association for the Study of the Liver.

94. Milani M, Annoni A, Moalli F, Liu T, Cesana D, Calabria A, Bartolaccini S, Biffi M, Russo F, Visigalli I, Raimondi A, Patarroyo-White S, Drager D, Cristofori P, Ayuso E, Montini E, Nichols TC, Peters R, Iannacone M, Cantore A#, Naldini L# (2019) Phagocytosis-shielded lentiviral vectors allow safe and robust liver gene transfer in non-human primates. Science Translational Medicine, 11:eaav7325 (#co-last authors)

95. Kuka M, De Giovanni M, Iannacone M (2019) The role of type I interferons in CD4+ T cell differentiation. Immunology Letters, 215:19

96. Thierry G, Kuka M, De Giovanni M, Mondor I, Brouilly I, Iannacone M#, Bajenoff M# (2018) The conduit system exports locally secreted IgM from lymph nodes. Journal of Experimental Medicine, 215:2972 (#co-last authors)

97. Pilipow K, Scamardella E, Puccio S, Gautam S, De Paoli F, Mazza EMC, De Simone G, Polletti S, Buccilli M, Zanon V, Di Lucia P, Iannacone M, Gattinoni L, Lugli E (2018) Antioxidant metabolism in activated CD8+ T cells regulates stem-like human memory T cell formation and anti-tumor immunity. JCI Insight, 3:e122299

98. Volpi VG, Pagani I, Ghezzi S, Iannacone M, D’Antonio M, Vicenzi E (2018) Zika virus replication in dorsal root ganglia explants causes myelin degeneration. Scientific Reports, 8:10166

99. Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck RV, Balmer J, Fiocchi A, Kreutzfeld M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV (2018) The Rho regulator Myosin IXb enables non-lymphoid tissue seeding of protective CD8+ T cells. Journal of Experimental Medicine, 215:1869

100. Vo HTM, Baudner BC, Sammicheli S, Iannacone M, D’Oro U, Piccioli D (2018) Alum/TLR7 adjuvant enhances the expansion of memory B cell compartment within the draining lymph node. Frontiers in Immunology, 9:641

101. Jofra T, Di Fonte R, Galvani G, Kuka M, Iannacone M, Battaglia M, Fousteri G (2018) Tr1 cell immunotherapy promotes transplant tolerance via de novo Tr1 cell induction and is safe and effective during acute viral infection in mouse. European Journal of Immunology, 48:1389

102. Sammicheli S, Kuka M, Iannacone M (2018) Intravital imaging of B cell responses in lymph nodes. Methods in Molecular Biology, 1763:63

103. De Giovanni M and Iannacone M (2018) In vivo imaging of adaptive immune responses to viruses. Current Opinion in Virology, 28:102

104. Kuka M and Iannacone M (2018) Viral subversion of B cell responses within secondary lymphoid organs. Nature Reviews Immunology, 18:255

105. Medaglia C*, Giladi A*, Stoler Barak L*, De Giovanni M*, Meir Salame T, Biram A, David E, Iannacone M#, Shulman Z#, Amit I# (2017) Spatial reconstruction of immune niches by combining photoactivatable fluorescent reporters and single-cell RNA-seq. Science, 358:1622 (*co-first authors; #co-last and co-corresponding authors)

106. Gaertner F, Ahmad Z, Rosenberg G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet AP, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Bottcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos y Schnitzler M, Pincus Z, Iannacone M, Hass R, Wanner G, Lauber K, Sixt M, Massberg S (2017) Migrating platelets are mechano-scavengers that collect and bundle bacteria. Cell, 171:1368

107. Kuka M and Iannacone M (2017) Intestinal flossing keeps pathogens at bay. Developmental Cell, 43:383

108. Pirzgalska RM, Seixas E, Seidman JS, Link VM, Martinez Sanchez N, Mahú I, Mendes R, Gres V, Kubasova N, Morris I, Arús BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass KC, Domingos AI (2017) Sympathetic associated macrophages clear norepinephrine and sustain obesity. Nature Medicine, 23:1309

109. Piergiovanni M, Bianchi E, Capitani G, Li Piani I, Ganzer L, Guidotti LG, Iannacone M, Dubini G (2017) Microcirculation in mouse liver lobule: a Computational Fluid Dynamic model based on 3D reconstruction from in vivo microscopy. Journal of Biomechanics, 63:125

110. Jimenez de Oya N, De Giovanni M, Fioravanti J, Ubelhart R, Di Lucia P, Fiocchi A, Iacovelli S, Efremov DG, Caligaris-Cappio F, Jumaa H, Ghia P, Guidotti LG, Iannacone M (2017) Pathogen-specific B cell receptors drive chronic lymphocytic leukemia by light chain-dependent cross-reaction with autoantigens. EMBO Molecular Medicine, 9:1482

111. Silvin A, Yu CI, Lahaye X, Imperatore F, Brault JB, Cardinaud S, Becker C, Kwan WH, Conrad C, Maurin M, Goudot C, Marques-Ladeira S, Wang Y, Pascual V, Anguiano E, Albrecht RA, Iannacone M, Garcia-Sastre A, Goud B, Dalod M, Moris A, Merad M, Palucka CA, Manel N (2017) Constitutive resistance to viral infection in human CD141+ dendritic cells. Science Immunology, 2:eaai8071

112. Jofra T, Di Fonte R, Kuka M, Mfarrej B, Iannacone M, Battaglia M, Fousteri G. (2017) Protein tyrosine phosphatase PTPN22 dampens T cell immune responses and drives 
viral persistence. Frontiers in Immunology, 8:811

113. Castiello MC, Pala F, Sereni L, Draghici E, Inverso D, Sauer AV, Schena F, Fontana E, Radaelli E, Uva P, Cervantes-Luevano KE, Benvenuti F, Poliani PL, Iannacone M, Traggiai E, Villa A, Bosticardo M (2017) In vivo chronic stimulation unveils intrinsic autoreactive potential of Wiskott-Aldrich syndrome protein-deficient B cells. Frontiers in Immunology, 8:490

114. Fioravanti J, Magini D, Di Lucia P, Boni C, Benechet AP, Inverso D, Fiocchi A, Wieland S, Purcell R, Ferrari C, Chisari FV, Guidotti LG, Iannacone M (2017) Effector CD8+ T cell-derived interleukin-10 enhances liver immunopathology. Journal of Hepatology, 67:543

115. Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W (2017) CD8+ T cells orchestrate pDC–XCR1+ dendritic cell spatial and functional cooperativity to optimize priming. Immunity, 46:205

116. Sammicheli S, Kuka M, Di Lucia P, Jimenez de Oya N, De Giovanni M, Fioravanti J, Cristofani C, Maganuco CG, Fallet B, Ganzer L, Sironi L, Mainetti M, Ostuni R, Larimore K, Greenberg PD, de la Torre JC, Guidotti LG, Iannacone M (2016) Inflammatory monocytes hinder antiviral B cell responses. Science Immunology, 1:eaah6789

117. Iannacone M (2016) Platelet-mediated modulation of adaptive immunity. Seminars in Immunology, 28:555

118. Benechet AP, Ganzer L, Iannacone M (2017) Intravital microscopy analysis of hepatic T cell dynamics. Methods in Molecular Biology, 1514:49

119. Benechet AP, Iannacone M (2017) Determinants of hepatic effector CD8+ T cell dynamics. Journal of Hepatology, 66:228

120. Iannacone M, Chisari FV, Guidotti LG (2016) Protective and Pathogenic T Cell Responses to Virus Infections. Encyclopedia of Immunobiology, 4:318

121. Catarinella M, Monestiroli A, Escobar G, Fiocchi A, Tran NL, Aiolfi R, Marra P, Esposito A, Cipriani F, Aldrighetti L, Iannacone M, Naldini L, Guidotti LG, Sitia G (2016) IFN gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment. EMBO Molecular Medicine, 8:155

122. Iannacone M, Guidotti LG (2015) Mouse models of HBV pathogenesis. Cold Spring Harbor Perspectives in Medicine, 5:a021477

123. Inverso D, Iannacone M (2016) Spatiotemporal dynamics of effector CD8+ T cell responses within the liver. Journal of Leukocyte Biology, 99:51

124. Iannacone M, Guidotti LG (2016) HBV Immunopathogenesis. In Hepatitis B Virus in Human Diseases, Molecular and Translational Medicine – Book series, Springer, 4:79

125. Guidotti LG, Inverso D, Sironi L, Di Lucia P, Fioravanti J, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Ganzer L, Cataudella T, Raimondi A, Gonzalez-Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M (2015) Immunosurveillance of the liver by intravascular effector CD8+ T cells. Cell, 161:486

126. Iannacone M, Guidotti LG (2015). Viral Pathogenesis. Current Opinion in Virology, 11:1 (invited section editor)

127. Maggioni D, Galli M, D'Alfonso L, Inverso D, Dozzi MV, Iannacone M, Collini M, Ferruti P, Ranucci E, D'Alfonso G (2015) A luminescent Poly(amidoamine)-Iridium complex as a new singlet-oxygen sensitizer for photodynamic therapy. Inorganic Chemistry, 54:544

128. Fousteri G, Jofra T, Di Fonte R, Kuka M, Iannacone M, Battaglia M (2014) PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner. Clinical Immunology, 156:98

129. Sironi L, Bouzin M, Inverso D, D’Alfonso L, Pozzi P, Cotelli F, Guidotti LG, Iannacone M, Collini M, Chirico G (2014) In Vivo Flow Mapping in Complex Vessel Networks by Single Image Correlation. Scientific Reports, 4:7341

130. Iannacone M (2015) Hepatic effector CD8+ T cell dynamics. Cellular and Molecular Immunology, 12:269

131. Ilyinskii PO, Roy CJ, O’Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Johnston LP, Kishimoto TK (2014) Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release. Vaccine, 32:2882

132. Kuka M, Iannacone M (2014) The role of lymph node sinus macrophages in host defense. Ann N Y Acad Sci, 1319:38

133. Tonti E, Jimenez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone M (2013) Bisphosphonates target B cells to enhance humoral immune responses. Cell Reports, 5:323

134. Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH (2013) Antigen availability determines CD8+ T cell-dendritic cell interaction kinetics and effector/memory fate decisions. Immunity, 39:496

135. Sitia G, Iannacone M, Guidotti LG (2013) Antiplatelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma. Journal of Hepatology, 59:1135

136. Guidotti LG, Iannacone M (2013) Effector CD8 T cell trafficking within the liver. Molecular Immunology, 55:94

137. Sung JH, Zhang H, Moseman EA, Alvarez D, Iannacone M, Henrickson SE, de la Torre JC, Luster AD, von Andrian UH (2012) Chemokine guidance of central memory T cells is critical for anti-viral recall responses in lymph nodes. Cell, 150:1249

138. Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F, Esposito A, Ruggeri ZM, Chisari FV, Iannacone M, Guidotti LG (2012) Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. PNAS, 109:E2165

139. Moseman EA*, Iannacone M*, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu Y-X, Hacohen N, von Andrian UH (2012) B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity, 36:415 (*co-first authors)

140. Tonti E, Fedeli M, Napolitano A, Iannacone M, von Andrian UH, Guidotti LG, Abrignani S, Casorati G, Dellabona P (2012) Follicular helper Natural Killer T cells provide CD1d-restricted help to B cells eliciting specific antibody responses in the absence of CD4+ T cells. Journal of Immunology, 188:3217

141. Chevrier N, Mertins P, Artyomov MN, Shalek AK, Garber M, Iannacone M, Ciaccio MF, Gat-Viks I, Eisenhaure TM, Clauser KR, Yosef N, Tonti E, Root DE, Beutler B, von Andrian UH, Jones RB, Park H, Carr SA, Regev A, Amit I, Hacohen N (2011) Systematic discovery of signaling components identifies new branches in viral-sensing pathways. Cell, 147:853

142. Sitia G*, Iannacone M*, Aiolfi R, Isogawa M, van Rooijen N, Scozzesi C, Bianchi ME, von Andrian UH, Chisari FV, Guidotti LG (2011) Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. PLoS Pathogens, 7:e1002061 (*co-first authors)

143. Iannacone M, Moseman EA, Tonti E, Bosurgi L, Henrickson SE, Whelan S, Guidotti LG, von Andrian UH (2010) Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature, 465:1079

144. Iannacone M, Sitia G, Guidotti LG (2009) On the role of platelets in the pathogenesis of viral hepatitis. Journal of Hepatology, 51:593

145. Iannacone M, Sitia G, Isogawa M, Whitmire JK, Marchese P, Chisari FV, Ruggeri ZM, Guidotti LG (2008) Platelets prevent IFN-ab-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. PNAS, 105:631

146. Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson S, Shayakhmetov DM, van Rooijen N, Mempel T, Whelan S., von Andrian UH (2007) Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature, 450:110

147. Iannacone M, Sitia G, Narvaiza I, Ruggeri ZM, Guidotti LG (2007) Antiplatelet Drug Therapy Moderates Immune-Mediated Liver Disease and Inhibits Viral Clearance in Mice Infected with a Replication-Deficient Adenovirus. Clinical and Vaccine Immunology, 14:1532

148. Nascimbene A, Iannacone M, Brando B, De Gasperi A (2007) Acute thrombocytopenia after liver transplant: Role of platelet activation, thrombopoietin deficiency and response to high dose intravenous IgG treatment. Journal of Hepatology, 47:651

149. Iannacone M, Sitia G, Ruggeri ZM, Guidotti LG (2007) HBV pathogenesis in animal models: recent advances on the role of platelets. Journal of Hepatology, 46:719

150. Sitia G*, Iannacone M*, Muller S, Bianchi ME, Guidotti LG (2007) Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice. Journal of Leukocyte Biology, 81:100 (*Co-first authors)

151. Iannacone M, Sitia G, Guidotti LG (2006) Pathogenetic and antiviral immune responses against Hepatitis B virus. Future Virology, 1:189

152. Iannacone M, Sitia G, Isogawa M, Marchese P, Castro MG, Lowenstein PR, Chisari FV, Ruggeri ZM, Guidotti LG (2005) Platelets mediate cytotoxic T lymphocytes-induced liver damage. Nature Medicine, 11:1167

153. Sitia G, Iannacone M, Chisari FV, Guidotti LG (2005) Pathogenesis of Hepatitis B Virus in Transgenic Mice. Models of viral hepatitis, Vol. 25. F. F. von Weizsacker, and M. E. Roggendorf, eds. Karger, Basel, Switzerland, p. 25

154. Rovere-Querini P, Capobianco A, Scaffidi P, Valentinis B, Catalanotti F, Giazzon M, Dumitriu IE, Muller S, Iannacone M, Traversari C, Bianchi ME, Manfredi AA (2004) HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Reports, 5:825

155. Sitia G, Isogawa M, Iannacone M, Campbell IL, Chisari FV, Guidotti LG (2004) MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs. Journal of Clinical Investigation, 113:1158

156. Manfredi AA, Iannacone M, D'Auria F, Rovere-Querini P (2002) The disposal of dying cells in living tissues. Apoptosis, 7:153

157. Bondanza A, Manfredi AA, Zimmermann VS, Iannacone M, Tincani A, Balestrieri G, Sabbadini MG, Querini PR (2001) Anti-beta2 glycoprotein I antibodies cause inflammation and recruit dendritic cells in platelet clearance. Thrombosis and Haemostasis, 86: 1257

158. Mauvais-Jarvis, F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR (2002) Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. Journal of Clinical Investigation, 109:141

CURRENT FUNDING:

FIS (Fondo Italiano per la Scienza) – Advanced Grant (FIS-2023-00745)
ACQUIRED IMMUNE CELL DYSFUNCTION AND RESTORATION IN CHRONIC HEPATITIS B
€2,008,980
2025 – 2028
Iannacone (Principal Investigator)

AIRC (Italian Association for Cancer Research) – Investigator Grant (30520)
BREAKING BARRIERS IN LIVER CANCER IMMUNOTHERAPY WITH ENDOTHELIAL REPROGRAMMING AND INNATE IMMUNE ACTIVATION
€1,782,000
2025 – 2029
Iannacone (Principal Investigator)

BioNTech
CHARACTERIZATION OF THE MODE OF ACTION OF BNT162b2
€900,000
2025-2028
Iannacone (Principal Investigator)

Gilead Sciences
INVESTIGATE EFFECTS OF PD1-TARGETED IL2V IN A HUPD1-KI HBV-TRANSGENIC MICE ADOPTIVE CELL TRANSFER MODEL
€510,000
2024 – 2027
Iannacone (Principal Investigator)

Horizon Europe Framework Programme – Doctoral Network (101167421)
UNDERSTANDING FRAILTY TOWARDS A FUTURE OF HEALTY AGING
€259,437
2025 –2029
Iannacone (Partner)

European Research Council – Advanced Grant (101141363)
ACQUIRED ADAPTIVE IMMUNE CELL DYSFUNCTION AND RESTORATION IN CHRONIC HEPATITIS B
€2,500,000
2024 –2029
Iannacone (Principal Investigator)

Medical Research Council – Developmental Pathway Funding Scheme (MR/Y019466/1)
DEVELOPING AN INFECTION-BLOCKING PAN-CORONAVIRUS VACCINE
£350,000
2024-2026
Iannacone (Co-Investigator)

AIRC (Italian Association for Cancer Research) – 5 per 1000 (22737)
ADVANCED IMMUNE GENE AND CELL THERAPIES FOR LIVER METASTASES
€678,172
2019 – 2026
Iannacone (Group Leader)

Italian Ministry for University and Research (Project no. PE00000007, INF-ACT)
EXTENDED PARTNERSHIP INITIATIVE ON EMERGING INFECTIOUS DISEASES
€450,000
2023-2025
Iannacone (Group Leader)

Italian Ministry for University and Research (PRIN 2022FMESXL)
MECHANISMS UNDERLYING DYSFUNCTIONAL CD8+ T CELL RESPONSES IN CHRONIC HEPATITIS B
€211,480
2023-2025
Iannacone (Coordinator)

SELECTED COMPLETED FUNDING:

European Research Council – Starting Grant (281648)
IN VIVO DYNAMICS OF ANTIBODY RESPONSES TO LYMPH-BORNE VIRUSES
€1,934,200
Mar 2012 – Jun 2017
Iannacone (Principal Investigator)

European Research Council – Proof of Concept Grant (957502)
IL-2 GENE THERAPY FOR CHRONIC HEPATITIS B VIRUS INFECTION
€150,000
Jul 2020 – Jun 2022
Iannacone (Principal Investigator)

European Research Council – Consolidator Grant (725038)
FUNCTIONAL BIOLOGY OF HEPATIC CD8+ T CELLS (FATE)
€2,390,000
Jul 2017 – Dec 2023
Iannacone (Principal Investigator)

European Research Council – Proof of Concept Grant (101138728)
SPIROCYCLIC CAMS AS NOVEL AND ULTRAPOTENT ANTI-HBV DRUGS
€150,000
2023 –2024
Iannacone (Principal Investigator)

Armenise-Harvard Foundation – Career Development Award
IN VIVO IMAGING OF ANTIVIRAL IMMUNE RESPONSES
$1,000,000
Nov 2010 – Oct 2015
Iannacone (Principal Investigator)

AIRC (Italian Association for Cancer Research) – Individual Grant MFAG (15350)
THE ROLE OF ANTIGENIC STIMULATION IN THE PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA
€225,000
Jan 2015 – Dec 2017
Iannacone (Principal Investigator)

AIRC (Italian Association for Cancer Research) – Program Project (9965)
HARNESSING TUMOUR CELL/MICROENVIRONMENT CROSS TALK TO TREAT MATURE B-CELL TUMOURS
€420,000
Nov 2010 – Oct 2015
Iannacone (Group Leader)

AIRC (Italian Association for Cancer Research) – Investigator Grant (19891)
SPATIOTEMPORAL DYNAMICS OF CD8+ T CELLS WITHIN LIVER TUMORS
€1,062,000
Jan 2018 – Dec 2023
Iannacone (Principal Investigator)

Italian Ministry of Health – Giovani Ricercatori (GR-2011-02347925)
DISSECTING HBV PATHOGENESIS THROUGH THE USE OF INTRAVITAL MICROSCOPY
€342,000
Nov 2014 – Nov 2017
Iannacone (Principal Investigator)

Italian Ministry of Health – Ricerca Finalizzata (RF-2018-12365801)
DETERMINANTS OF INTRAHEPATIC CD8+ T CELL PRIMING
€450,000
Jul 2020 – Jun 2023
Iannacone (Principal Investigator)

Gilead Sciences
THE CAPACITY OF IL-2 MOLECULES TO INCREASE THE NUMBER AND/OR FUNCTION OF INTRAHEPATICALLY PRIMED HBV-SPECIFIC CD8+ T CELLS
€631,875
2019-2022
Iannacone (Principal Investigator)

Asher Biotherapeutics
TO DETERMINE THE CAPACITY OF CD8-TARGETED IL-2 MOLECULES TO INCREASE THE NUMBER AND/OR FUNCTION OF INTRAHEPATICALLY PRIMED HBV-SPECIFIC CD8+ T CELLS
€447,550
2021-2023
Iannacone (Principal Investigator)

HumAbs / VIR Biotechnology
TO CHARACTERIZE THE IN VIVO EFFECT OF HUMAN MONOCLONAL ANTIBODIES AGAINST HBV
€194,250
2023-2024
Iannacone (Principal Investigator)