Insulin resistance disrupts white matter microstructure and amplitude of functional spontaneous activity in Bipolar Disorder
Articolo
Data di Pubblicazione:
2023
Citazione:
Insulin resistance disrupts white matter microstructure and amplitude of functional spontaneous activity in Bipolar Disorder / Mazza, Elena; Calesella, Federico; Paolini, Marco; di Pasquasio, Camilla; Poletti, Sara; Lorenzi, Cristina; Falini, Andrea; Zanardi, Raffaella; Colombo, Cristina; Benedetti, Francesco. - In: BIPOLAR DISORDERS. - ISSN 1398-5647. - 25:1(2023), pp. 32-42. [Epub ahead of print] [10.1111/bdi.13270]
Abstract:
Bipolar disorder (BD) is linked to several structural and functional brain alterations. In addition, BD patients have a three-fold increased risk of developing insulin resistance, which is associated with neural changes and poorer BD outcomes. Therefore, we investigated the effects of insulin and two derived measures (insulin resistance and sensitivity) on white matter (WM) microstructure, resting-state (rs) functional connectivity (FC), and fractional amplitude of low frequency fluctuation (fALFF).
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Bipolar Disorder; HOMA-IR; TBSS; fALFF; inflammation; insulin; white matter
Elenco autori:
Mazza, Elena; Calesella, Federico; Paolini, Marco; di Pasquasio, Camilla; Poletti, Sara; Lorenzi, Cristina; Falini, Andrea; Zanardi, Raffaella; Colombo, Cristina; Benedetti, Francesco
Link alla scheda completa:
Pubblicato in: