Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus
Articolo
Data di Pubblicazione:
2017
Citazione:
Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus / Puoti, M.; Lorenzini, P.; Cozzi-Lepri, A.; Gori, A; Mastroianni, C; Rizzardini, G; Mazzarello, G; Antinori, A; D'Arminio Monforte, A; Girardi, E; on behalf of the Icona Fdn Study, Grp; Castagna, A. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - 23:4(2017), pp. 267-267.e4. [10.1016/j.cmi.2016.12.003]
Abstract:
Objective To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection. Methods We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy. Results Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion. Conclusions New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Cirrhosis; Cohort study; Hepatitis C virus; Human immunodeficiency virus; Incidence; Cohort Studies; Disease Progression; Female; HIV Infections; Hepatitis C; Humans; Incidence; Italy; Kaplan-Meier Estimate; Liver Cirrhosis; Male; Population Surveillance; Risk; Coinfection; Microbiology (medical); Infectious Diseases
Elenco autori:
Puoti, M.; Lorenzini, P.; Cozzi-Lepri, A.; Gori, A; Mastroianni, C; Rizzardini, G; Mazzarello, G; Antinori, A; D'Arminio Monforte, A; Girardi, E; on behalf of the Icona Fdn Study, Grp; Castagna, A
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