From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio
Academic Article
Publication Date:
2021
abstract:
Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.
Iris type:
1.1 Articolo in rivista
Keywords:
Animals; COVID-19; Chilblains; Humans; Immunity, Innate; Interferon Type I; SARS-CoV-2
List of contributors:
Arkin, L. M.; Moon, J. J.; Tran, J. M.; Asgari, S.; O'Farrelly, C.; Casanova, J. -L.; Cowen, E. W.; Mays, J. W.; Singh, A. M.; Drolet, B. A.; Aiuti, A.; Belot, A.; Bolze, A.; Bondarenko, A.; Sediva, A.; Shcherbina, A.; Planas, A. M.; Condino-Neto, A.; Pujol, A.; Catherine, B.; Flores, C.; Rodriguez-Gallego, C.; Prando, C.; Dalgard, C. L.; O'Farrelly, C.; Roger, C.; Mansouri, D.; van de Beek, D.; Vinh, D. C.; Hsieh, E.; Andreakos, E.; Haerynck, F.; Uddin, F.; Casari, G.; Novelli, G.; Pesole, G.; Meyts, I.; Tancevski, I.; Fellay, J.; Tur, J.; Kisand, K.; Okamoto, K.; Mironska, K.; Abel, L.; Renia, L.; Ng, L. F. P.; Shahrooei, M.; Soler-Palacin, P.; Brodin, P.; Pan-Hammarstrom, Q.; Halwani, R.; Perez de Diego, R.; Al-Muhsen, S.; Espinosa-Padilla, S.; Okada, S.; Ozcelik, T.; Tayoun, A. A.; Karamitros, T.; Mogensen, T. H.; Lau, Y. -L.
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