Antidepressant chronotherapeutics normalizes prefrontal 1H-MRS glutamate in bipolar depression
Academic Article
Publication Date:
2022
abstract:
Dysfunctional glutamatergic neurotransmission has been proposed both, as a biological underpinning of mood disorder and as a target for rapid-acting antidepressant treatments. Total sleep deprivation and light therapy (TSD + LT) can prompt antidepressant response in drug-resistant bipolar depression. Here we explored the effects of TSD + LT on dorsolateral prefrontal cortex (DLPFC) glutamate and/or glutamine+glutamate (Glx) levels.
Iris type:
1.1 Articolo in rivista
Keywords:
Bipolar disorder; Chronoterapeutics; Clinical biomarker; Glutamate; Spectroscopy; Antidepressive Agents; Drug Chronotherapy; Glutamic Acid; Glutamine; Humans; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Bipolar Disorder; Depressive Disorder, Major
List of contributors:
Melloni, Elisa M T; Bravi, Beatrice; Poletti, Sara; Dallaspezia, Sara; Barbini, Barbara; Zanardi, Raffaella; Benedetti, Francesco
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