Publication Date:
2011
abstract:
P>To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age > 60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.
Iris type:
1.1 Articolo in rivista
List of contributors:
Chigrinova, E; Mian, M; Shen, Yl; Greiner, Tc; Chan, Wc; Vose, Jm; Inghirami, G; Chiappella, A; Baldini, L; Ponzoni, Maurilio; Ferreri, Ajm; Franceschetti, S; Gaidano, G; Tucci, A; Facchetti, F; Lazure, T; Lambotte, O; Montes Moreno, S; Piris, Ma; Zucca, E; Kwee, I; Bertoni, F.
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