In Regard to Zureick et al.

In 375 patients with left-sided breast cancer treated between 2012 and 2018 with adjuvant radiation therapy using mainly deep-inspiratory breath-holding technique (78% of patients), Zureick et al 1 analyzed mean and maximum left anterior descending artery (LAD) and heart dose association with cardiac toxicity. Considering even moderate cardiac events, the authors identified, with median 48-month follow-up, higher risk for cardiac events above the following thresholds: LAD Dmean Equivalent Dose in 2 Gy fractions of 2.8 Gy, Dmax of 6.7 Gy, and heart Dmean of 0.8 Gy.