EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide
Articolo
Data di Pubblicazione:
2015
Citazione:
EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide / Cominelli, Manuela; Grisanti, Salvatore; Mazzoleni, Stefania; Branca, Caterina; Buttolo, Luciano; Furlan, Daniela; Liserre, Barbara; Bonetti, Maria Fausta; Medicina, Daniela; Pellegrini, Vilma; BUGLIONE DI MONALE E BASTIA, Michela; Liserre, Roberto; Pellegatta, Serena; Finocchiaro, Gaetano; Dalerba, Piero; Facchetti, Fabio; Pizzi, Marina; Galli, Rossella; Poliani, Pietro Luigi. - In: JOURNAL OF THE NATIONAL CANCER INSTITUTE. - ISSN 0027-8874. - 107:5(2015). [10.1093/jnci/djv041]
Abstract:
Lack of robust predictive biomarkers, other than MGMT promoter methylation, makes temozolomide responsiveness in newly diagnosed glioblastoma (GBM) patients difficult to predict. However, we identified patients with long-term survival (≥35 months) within a group of newly diagnosed GBM patients treated with standard or metronomic adjuvant temozolomide schedules. We thus investigated possible molecular profiles associated with longer survival following temozolomide treatment.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Adult; Analysis of Variance; Antineoplastic Agents; Alkylating; Brain Neoplasms; Chemotherapy; Adjuvant; Dacarbazine; Disease-Free Survival; Female; Gene Amplification; Gene Expression Regulation; Neoplastic; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplastic Stem Cells; Odds Ratio; Proportional Hazards Models; Receptor; Epidermal Growth Factor; Up-Regulation; Administration; Metronomic
Elenco autori:
Cominelli, Manuela; Grisanti, Salvatore; Mazzoleni, Stefania; Branca, Caterina; Buttolo, Luciano; Furlan, Daniela; Liserre, Barbara; Bonetti, Maria Fausta; Medicina, Daniela; Pellegrini, Vilma; BUGLIONE DI MONALE E BASTIA, Michela; Liserre, Roberto; Pellegatta, Serena; Finocchiaro, Gaetano; Dalerba, Piero; Facchetti, Fabio; Pizzi, Marina; Galli, Rossella; Poliani, Pietro Luigi
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