Non functional pancreatic neuroendocrine tumors

Nonfunctioning Pancreatic Neuroendocrine Neoplasia (NF-PanNEN) are a wide group of heterogeneous tumors, increasingly diagnosed in recent years. NF-PanNEN are classified in different categories based on Ki67 proliferation index and their morphology (well differentiated PanNEN, poorly differentiated pancreatic neuroendocrine carcinoma and mixed neuroendocrine-non neuroendocrine neoplasia). Preoperative evaluation of NF-PanNEN consists of both conventional morphological radiological examination and functional imaging. Treatment depends on several factors such as stage, patient characteristics, and aggressiveness of disease. Surgical management of NF-PanNEN is highly variable ranging from observation for small asymptomatic lesions to multivisceral resection in advanced forms. A multidisciplinary tailored approach is always recommended for choosing the best management in patients affected by NF-PanNEN.