Pegvisomant and Pasireotide LAR as second line therapy in acromegaly: clinical effectiveness and predictors of response

Background: The treatment of acromegaly resistant to first-generation somatostatin receptor ligands (SRLs) is often difficult. Pegvisomant and Pasireotide LAR are mostly used in these subset of patients, as second line therapies. Choice of the type of second line therapies is difficult, since predictors of response are still unclear, impairing personalized therapy. We aimed to investigate predictors of response to Pegvisomant and Pasireotide LAR.Methods: Seventy-four acromegaly patients entered this observational, cross-sectional and retrospective study if (i) resistant to high dose first-generation SRLs and (ii) treated with Pegvisomant and Pasireotide LAR for at least 12 consecutive months. Patients treated with radiotherapy in the previous 10 years were excluded.Results: Fourty-one patients were treated with Pegvisomant and 33 with Pasireotide LAR. At the end of the study, acromegaly was controlled in 35 patients treated with Pegvisomant (85.4%) and in 23 treated with Pasireotide LAR (69.7%). In this cohort, a poor Pegvisomant response and a shorter progression free time were observed in cases with tumor extension to the third ventricle (P = 0.004, HR: 1.6, 95% CI: 1.2-4.6), with a Ki67-Li >4% (P = 0.004, HR: 3.49, 95% CI: 1.4-4.0) and with pre-treatment IGF-I >3.3xULN (P = 0.03, HR: 1.3, 95% CI: 1.1-6.0). A poor Pasireotide LAR response and a shorter progression free time were observed in cases with tumor extension to the third ventricle (P = 0.025, HR: 1.6 95% Cl: 1.4-3.4), pre-treatment IGF-I >2.3xULN (P = 0.049, HR: 2.4, 95% CI: 1.4-8.0), absent/low SSTS membranous expression (P = 0.023 HR: 4.56 95% CI: 1.3-6.4) and in patients carried the d3-delated GHR isoform (P = 0.005, HR: 11.37, 95% CI: 1.3-20.0).Conclusion: Molecular and clinical biomarkers can be useful in predicting the responsiveness to Pegvisomant and Pasireotide LAR.