Data di Pubblicazione:
2009
Citazione:
Common variants at five new loci associated with early-onset inflammatory bowel disease / Imielinski, M.; Baldassano, R. N.; Griffiths, A.; Russell, R. K.; Annese, V.; Dubinsky, M.; Kugathasan, S.; Bradfield, J. P.; Walters, T. D.; Sleiman, P.; Kim, C. E.; Muise, A.; Wang, K.; Glessner, J. T.; Saeed, S.; Zhang, H.; Frackelton, E. C.; Hou, C.; Flory, J. H.; Otieno, G.; Chiavacci, R. M.; Grundmeier, R.; Castro, M.; Latiano, A.; Dallapiccola, B.; Stempak, J.; Abrams, D. J.; Taylor, K.; Mcgovern, D.; Heyman, M. B.; Ferry, G. D.; Kirschner, B.; Lee, J.; Essers, J.; Grand, R.; Stephens, M.; Levine, A.; Piccoli, D.; Van Limbergen, J.; Cucchiara, S.; Monos, D. S.; Guthery, S. L.; Denson, L.; Wilson, D. C.; Grant, S. F. A.; Daly, M.; Silverberg, M. S.; Satsangi, J.; Hakonarson, H.. - In: NATURE GENETICS. - ISSN 1061-4036. - 41:12(2009), pp. 1335-1340. [10.1038/ng.489]
Abstract:
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 × 10 9), 22q12 (rs2412973, P = 1.55 × 10 9), 10q22 (rs1250550, P = 5.63 × 10 9), 2q37 (rs4676410, P = 3.64 × 10 8) and 19q13.11 (rs10500264, P = 4.26 × 10 10). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early-and adult-onset IBD. © 2009 Nature America, Inc. All rights reserved.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Imielinski, M.; Baldassano, R. N.; Griffiths, A.; Russell, R. K.; Annese, V.; Dubinsky, M.; Kugathasan, S.; Bradfield, J. P.; Walters, T. D.; Sleiman, P.; Kim, C. E.; Muise, A.; Wang, K.; Glessner, J. T.; Saeed, S.; Zhang, H.; Frackelton, E. C.; Hou, C.; Flory, J. H.; Otieno, G.; Chiavacci, R. M.; Grundmeier, R.; Castro, M.; Latiano, A.; Dallapiccola, B.; Stempak, J.; Abrams, D. J.; Taylor, K.; Mcgovern, D.; Heyman, M. B.; Ferry, G. D.; Kirschner, B.; Lee, J.; Essers, J.; Grand, R.; Stephens, M.; Levine, A.; Piccoli, D.; Van Limbergen, J.; Cucchiara, S.; Monos, D. S.; Guthery, S. L.; Denson, L.; Wilson, D. C.; Grant, S. F. A.; Daly, M.; Silverberg, M. S.; Satsangi, J.; Hakonarson, H.
Link alla scheda completa:
Pubblicato in: