Hypoxia pathway: 18F-FAZA

Hypoxia plays a crucial role in various cellular events, including proliferation, survival, angiogenesis, immuno-surveillance, metabolism, as well as in tumour invasion and metastasis. This chapter will describe the current knowledge on technical procedures of radiosynthesis, features of biodistribution, and current research on potential clinical application of 18F-FAZA PET as a radiopharmaceutical agent able to assess the hypoxia expression in neoplastic cells.