Spectral-domain Optical Coherence Tomography Of Early Onset Large Colloid Drusen

Purpose:Large colloid drusen (LCD) are a kind of early onset drusen (EOD) which have recently been reported. Aim of this study was to describe morphological features in patients affected with LCD using high-resolution spectral domain optical coherence tomography (SD-OCT).

Methods:Complete ophthalmologic examination including spectral domain OCT, was performed in 22 eyes of 11 consecutive patients

Results:Mean age was 35 years old at diagnosis and mean visual acuity was 20/25. SD-OCT scans showed in all eyes multiple dome-shaped RPE detachments corresponding to the drusen. Most LCD appeared convex with medium and homogeneous internal reflectivity. Retina overlying LCD appeared wavy and overall thinned. Prominent diffuse hyper reflective haze in the photoreceptor nuclear layer over drusen was noted in 73%. We did not observe any association with geographic atrophy or choroidal neovascularization in none of the 22 eyes.

Conclusions:The peculiar SD-OCT features reported in the current series give insight on the histology of LCD. Further studies with follow-up evaluation and possibly histological evaluation are needed to clarify the clinical significance of LCD.