Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells
Academic Article
Publication Date:
2013
Short description:
Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells / Mazzucchelli, S., Colombo, M., Verderio, P., Rozek, E., Andreata, F., Galbiati, E., Tortora, P., Corsi, F., Prosperi, D.. - In: ANGEWANDTE CHEMIE. - ISSN 1521-3773. - 52:11(2013), pp. 3121-3125. [10.1002/anie.201209662]
abstract:
In control: The ligand positioning and orientation on multifunctional nanoparticles (MNP) are controlled by using a versatile bimodular approach that exploits an 11 amino acid (U11) homing peptide genetically fused with a haloalkane dehalogenase (HALO) enzyme. The resultant nanoparticles have good targeting efficiency and selectivity toward broadly occurring urokinase plasminogen activator receptor positive human cancer cells. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Iris type:
1.1 Articolo in rivista
Keywords:
multifunctional nanoparticles; homing peptides; uPAR; bioconjugation; cell targeting; bioconjugation; cell targeting; nanoparticles; peptides; receptors
List of contributors:
Mazzucchelli, Serena; Colombo, Miriam; Verderio, Paolo; Rozek, E; Andreata, F; Galbiati, Elisabetta; Tortora, Paolo; Corsi, F; Prosperi, Davide
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