Reduced levels of free testosterone in four Catania-type alloalbuminemic males

We studied total testosterone, sex hormone binding globulin, and free testosterone in four males presenting an electrophoretically slow-moving genetic variant of albumin, the alloalbumin Catania. Free testosterone levels were lower in these cases, found in a year of observation, than those expected for the ages. This finding, which is not related to any disease and constantly not recognized in other males with various genetic variants, should induce consideration of a probable difference of the genetic variant in hormone binding.