Treatment options for diffuse diabetic macular edema

PURPOSE. To describe the current management of diffuse diabetic macular edema (DOME). METHODS. Review and discussion of the literature regarding DOME. RESULTS. Diffuse diabetic macular edema is a condition that can be managed by means of several treatment options, including focal/grid laser photocoagulation, intravitreal or periocular corticosteroids, intravitreal anti-vascular endothelial growth factor (VEGF), and vitrectomy with or without internal limiting membrane peeling. CONCLUSIONS. Even though there is no randomized clinical trial specifically designed to assess the best treatment approach for DOME, new therapeutic approaches based on intravitreal injections of corticosteroid and anti-VEGF molecules offer new hope for its management.