Differentiation of Sendai virus-reprogrammed iPSC into β cells, compared with human pancreatic islets and immortalized β cell line

New sources of insulin-secreting cells are strongly in demand for treatment of diabetes. Induced pluripotent stem cells (iPSCs) have the potential to generate insulin-producing cells (iβ). However, the gene expression profile and secretory function of iβ still need to be validated in comparison with native β cells.