Data di Pubblicazione:
2019
Citazione:
PRDM12 is required for initiation of the nociceptive neuron lineage during neurogenesis / Bartesaghi, Luca; Wang, Yiqiao; Fontanet, Paula; Wanderoy, Simone; Berger, Finja; Wu, Haohao; Akkuratova, Natalia; Bouçanova, Filipa; Médard, Jean-Jacques; Petitpré, Charles; Landy, Mark A.; Zhang, Ming-Dong; Harrer, Philip; Stendel, Claudia; Stucka, Rolf; Dusl, Marina; Eleni Kastriti, Maria; Croci, Laura; Lai, Helen C.; Consalez, GIANGIACOMO GERMANO; Pattyn, Alexandre; Ernfors, Patrik; Senderek, Jan; Adameyko, Igor; Lallemend, Francois; Hadjab, Saida; Chrast, Roman. - In: CELL REPORTS. - ISSN 2211-1247. - 26:13(2019), pp. 3484-3492. [10.1016/j.celrep.2019.02.098]
Abstract:
Mutations in PRDM12 cause congenital insensitivity to pain, yet the mechanistic insights on the causative deficits are missing. Here we report that loss of PRDM12 function in mice results in a complete, selective absence of nociceptive neurons. Forcing PRDM12 expression in neural crest cells alters their neurogenic potential, but is not sufficient to drive the nociceptive neuron fate. These data reveal that PRDM12 is necessary for the generation of pain initiating neuron types during development.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Bartesaghi, Luca; Wang, Yiqiao; Fontanet, Paula; Wanderoy, Simone; Berger, Finja; Wu, Haohao; Akkuratova, Natalia; Bouçanova, Filipa; Médard, Jean-Jacques; Petitpré, Charles; Landy, Mark A.; Zhang, Ming-Dong; Harrer, Philip; Stendel, Claudia; Stucka, Rolf; Dusl, Marina; Eleni Kastriti, Maria; Croci, Laura; Lai, Helen C.; Consalez, GIANGIACOMO GERMANO; Pattyn, Alexandre; Ernfors, Patrik; Senderek, Jan; Adameyko, Igor; Lallemend, Francois; Hadjab, Saida; Chrast, Roman
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